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《Chinese Journal of Clinical Pharmacology and Therapeutics》 2007-02
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Evaluation of anti-inflammatory effects of luteolin and underlying mechanisems

TANG Ning1,2,LI Zi-yan1,ZHOU Yong-mei1,LIU Bao-lin11 Department of Pharmacology of Chinese Material Medica,China Pharmaceutical University,Nanjing 210038,Jiangsu,China;2Life Science Department,Nanjing Xiaozhuang College,Nanjing 211171,Jiangsu,China  
AIM:To investigate anti-inflammatory effects of luteolin and underlying mechanisems.METHODS:Three typical inflammatory models,carrageenan-induced paw edema,cotton pellet granuloma and air cyst were used to investigate anti-inflammatory effect of luteolin in vivo.Meanwhile,effects of luteolin on mitogen-induced splenocyte proliferation and cyclooxygenase(COX)activities in vitro were also studied.RESULTS:Luteolin reduced the carrageenan-induced paw edema and effectively inhibited the inflammatory process in the cotton pellet granuloma model.Luteolin significantly inhibited leukocytes influx and reduced elevated levels of PGE2 and 6-keto-PGF1α in the exude induced by carrageenan injection.ConA stimulated splenocyte to proliferate,and the response was effectively suppressed by luteolin.In the whole blood assay,luteolin demonstrated selective inhibition of COX-2 activity.CONCLUSION:Luteolin effectively suppresses inflammatory responses in vivo,and the anti-inflammatory activity is associated with its selective inhibition of COX-2.
【Fund】: 南京晓庄学院校级重点学科生态学资助项目(2005-2008)
【CateGory Index】: R285
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