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《Chinese Journal of Clinical Pharmacology and Therapeutics》 2007-05
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Effects of cinobufacine on intracellular adriamycin accumulation in human breast cancer cells

WANG Ling1, LIU Shi-kun2, ZHOU Yu-lu2, PEI Qi2, YANG Ning31Yongzhou Vocation-technical college, Yongzhou 425006, Hunan, China; 2Department of Pharmacy, the Third Affiliated Hospital of Xiangya, Zhongnan University, Changsha 410006, Hunan, China; 3Yongzhou People's Hospital, Yongzhou 425006, Hunan, China  
AIM: To study the effects of cinobufacine on intracellular adriamycin accumulation in human breast cancer MCF-7/ADM cells, and further explore the mechanism of cinobufacine reversing the multidrug resistance of human breast cancer MCF-7/ADM cells. METHODS: The cytotoxic effect was determined by MTT assay. Intracellular ADM concentration was examined by HPLC. RESULTS: 15 mg/L cinobufacine decreased the IC50 of ADM to MCF-7/ADM cells from 38.14 mg/L to 12.93 mg/L, but increased intracellular adriamycin accumulation in MCF-7/ADM cells. CONCLUSION: Cinobufacine can increase intracellular ADM accumulation and partly reverse MDR of MCF-7/ADM cell line.
【Fund】: 湖南省卫生厅科研基金资助课题(2004-073)
【CateGory Index】: R285.5
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