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《Chinese Journal of Clinical Pharmacology and Therapeutics》 2008-10
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Effects of the erigeron injection on liver microsomal cytochrome P450 system in mice

XU Li-jun1,JU Wen-zheng2,CHEN Wei-kao1,TAN Heng-shan31College of Pharmacy,Nanjing University of Traditional Chinese Medicine,Nanjing 210029,Jiangsu,China;2Department of Clinical Pharmacology,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210029,Jiangsu,China;3General Hospital of Armed Forces of Nanjing,Nanjing 210002,Jiangsu,China  
AIM:To investigate the effects of erigeron injection on liver microsomal cytochrome P450(CYP450)system in mice.METHODS:Mice were divided into control group(CG),positive control group,normal-dosage group(NG) and high-dosage group(HG).The mice of control group were given saline only and the mice of positive control group were given Phenobarbital sodium injection(PBN) at 80 mg/kg by peritoneal injection(i.p.),once daily for seven days.The remaining two groups were i.p.with 10 mg/kg(normal-dosage group) and 30 mg/kg(high-dosage group) erigeron injection,respectively,once daily for two weeks.Then the total content and activities of CYP450 of mice were determined by spectrophotometer.RESULTS:The study showed that the content of CYP450 and protein in mice of normal-dosage group and high-dosage group were higher than those in control group,except liver indexes.In terms of the erigeron injection effects on Erythromycin-N-demethylase and aminopyrine-N-demethylase,the normal-dosage group and high-dosage group can decrease the activity of Erythromycin-N-demethylase(P0.01),but had no effect on aminopyrine-N-demethylase(P0.05).Phenobarbital sodium can increase the levels of liver indexes,the content of CYP450 and protein(P0.05),Erythromycin-N-demethylase and aminopyrine-N-demethylase(P0.01).CONCLUSION:The erigeron injection had no effect on the liver indexes and the levels of aminopyrine N-demethylase in mice.However,the content of CYP450 and protein,and the levels of Erythromycin N-demethylase were affected.The erigeron injection may be an inhibitive agent to CYP3A.
【Fund】: 科技部“十一五”支撑计划课题-药物临床研究关键技术研究与应用(2006BAI14B07)
【CateGory Index】: R285
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