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《Chinese Journal of Clinical Pharmacology and Therapeutics》 2012-10
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Huperzine A enhances excitatory synaptic transmission in CA1 pyramidal neurons of adult rat hippocampal slices

WU Xiao-wei1,2,WANG Bang-an1,WANG Meng-ya1 1 Cell Electrophysiology Laboratory,Wannan Medical College,Wuhu 241002,Anhui,China;2 Department of Neurology,Fuxing Hospital of Capital Medical University,Beijing 100038,China  
AIM: To observe the effects of huperzine A(Hup-A) on excitatory synaptic transmission in CA1 pyramidal neurons of adult rat hippocampal slices and to gain an insight into the cellular electrophysiological mechanisms underlying the potentiation of learning and memory by Hup-A.METHODS: The intracellular recordings from CA1 pyramidal neurons in hippocampal slices related to learning and memory were made to analyze mechanisms of Hup-A actions on cell electrophysiological properties and excitatory postsynaptic potential(EPSP) evoked by stimulating Schaffer collaterals.RESULTS:(1) During bath of Hup-A(1 μmol/L),the changes of cell electrophysiological properties were not significant(P0.05).(2) Superfusion of Hup-A(0.3-3.0 μmol/L,15 min) increased amplitude,duration and area under curve of EPSPs,which was concentration-dependent,recoverable,but sensitive to atropine pretreatment(10 μmol/L,n=4).(3) Hup-A did not result in remarkable changes of depolarizing response induced by exogenous glutamate(n=5).CONCLUSION: By the facilitation of the synaptic transmissions,Hup-A may potentiate the activities of hippocampal CA1 pyramidal neurons,and its actions on EPSP is related to the excitation of muscarinic type of acetylcholinergic receptors.
【Fund】: 安徽省自然科学基金项目(090413084);; 国家自然科学基金(30270366)项目
【CateGory Index】: R965.2
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1 CHENG Jing;LI Cheng-yan;WANG Gao-hua;CHEN Zheng-hua;XIAO Ling;Department of Psychiatry, Renmin Hospital of Wuhan University;Department of Neurology, Renmin Hospital of Wuhan University;;The Effects of Huperzine A on Memory and ARC of ECT Rats[J];Progress in Modern Biomedicine;2013-27
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