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《Chinese Journal of Difficult and Complicated Cases》 2009-01
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Research on cerebral neurotransmitters of Parkinson’s disease with encephalofluctuograph technology

LI Jun-yan,YANG Ming-hui,ZHAO Guan-ying,et al.Institute of Traditional Chinese Medicine,General Hospital of PLA, Beijing 100853,China  
Objective To explore the changes of cerebral neurotransmitters in patients with Parkinson’s Disease(PD).Methods The changes of neurotransmitters were observed with encephalofluctuograph technology(ET) in 52 cases of PD patients (51~60 years 26 cases and 61~70 years 26 cases). All patients were observed 48 hours after medication withdrawal or non medication yet. Besides, 34 cases which treated with Benserazide were obsreved one more time 1.5 hours after medication.Results The level of NE and DA in all cases was declined obviously(P0.05 or P0.01),the same result displayed in 5-HT,yet no statistically significant (P0.05).The level of Ach increased in 61~70 years group obviously (P0.05).Compared with 51~60 years group,the level of DA in 61~70 years group was declined more significantly (P0.05).After administrated Benserazide in 34 cases of PD patients,the levels of NE,5-HT,and DA were increased obviously(P0.05).Conclusion It demonstrated that the levels of DA, NE and 5-HT in PD patients were declined in differential extent.The changes of the cerebral neurotransmitters were different according to ages.The changes of neurotransmitters in brain could provide valuable reference for early diagnosis and therapy of PD with encephalofluctuograph technology.
【Fund】: 国家“十一五”科技支撑计划重大疑难疾病项目(No.2006BAI04A11-1)
【CateGory Index】: R742.5
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