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《Chinese Journal of Difficult and Complicated Cases》 2009-04
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Experimental study of inhaling Xuebijing aerosol on acute lung injury

XU Peng,ZHANG Hua,SU Ren-yi,et al.Department of Emergency,the Xiangfan First People's Hospital,Hubei,Xiangfan 441000,China  
Objective To study the therapeutic effect of inhaling Xuebijing aerosol on acute lung injury(ALI)induced with lipopolysaccharide(LPS).Methods The ALI model was built in 54 Wistar rats,which induced by injecting LPS(5 mg/kg)through tail vein.All rats were randomized into 3 groups,including normal control group(A group),of which inhaling saline;ALI model group(B group),of which injecting LPS through tail vein and inhaling saline;treatment group(C group),of which injecting LPS through tail vein and inhaling Xuebijing aerosol.At 2 h,2nd day and 7th day after model built,6 rats of each group were put to death and lung section was collected.Detecting the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),thromboxane B2(TXB2)of serum,and expression of myeloperoxidase(MPO)in lung tissue,to measure the arterial blood gas analysis,lung index,wet/dry weight,water ratio,and the pathologic changes in lung were observered with HE stained sections.Results Compared with the normal control group,LPS induced group(B group)exhibited higher levels of TNF-α,IL-6,TXB2 of serum and MPO of rat lung tissue(P0.01 or P0.05).Furthermore,the lung index wet/dry weight and water ratio were significantly higher in B group than A group(P0.05).In C group,all indexes obvious improved than other groups(P0.05).Additional,the PaO2 decreased in B group(P0.01),while PaCO2 increased than A group(P0.05).In C group,the PaO2 increased,while PaCO2 decreased than B group(P0.05).Observing with general sample and microscope,the pathological change was obvious in B group,which was more severe than C group.Conclusion It demonstrated that inhaling Xuebijing aerosol had protective effect on lung tissue of ALI which induced by endotoxin.
【CateGory Index】: R563.8
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