Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Difficult and Complicated Cases》 2013-02
Add to Favorite Get Latest Update

The expression levels of serum interleukin-17 and leukotriene B4 in children with bronchial asthma and its clinical value

HAO Jian-cheng,ZHANG Yu-xia,CHEN Xiao-qin.Department of Pediatrics,the First Hospital of Fangshan District, Beijing 102400,China  
Objective To evaluate the expression levels of serum interleukin-17(IL-17),leukotriene B4(LTB4) in children with bronchial asthma.Methods 62 children with acute asthma were selected as acute attack group,and 37 children were selected as remission group from relieve after treatment of the acute asthma.We also selected 30 children as healthy control. PMN was determined with automatic blood analyzer,and Thl7 cells were measured with(low cytometry.And the level of serum IL-17 and LTB4 were determined by ELISA.Results The levels of IL-17 and LTB4 in the acute attack group were higher than those in the remission group and the healthy control(P 0.05).There were no significant differences of the serum (L-17 and LTB4 between remission group and healthy control(P 0.05).There was no significant difference of total peripheral white cell count(P 0.05),but there were significant differences of PMN,Thl7 cells and lymphocyte between the acute attack group and the two control groups(P 0.05).The correlation analysis shows that the level of IL-17 was positively correlated to LTB4 in asthmatic children(r =0.934,P 0.05).And there were positive correlations between the serum IL-17,LTB4 and PMN,Th17 cells(r =0.398,P 0.05;r =0.391,P 0.05;r =0.856,P 0.05;r =0.759,P 0.01).Conclusion It demonstrated that the Thl7 cells,IL-17,PMN and LTB4 played important roles in the pathogenesis of asthma.
【CateGory Index】: R725.6
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 7 Hits
1 Huang Han;Zhang Xiangfeng;Lu Hongxia;Department of Respiration,Zhengzhou Children's Hospital;;Effect of Huaiqihuang granules in preventing and treating bronchial asthma and influence on immunological function in children[J];中国医药;2016-09
2 YANG Shumei;WANG Lijun;SUN Yu;HU Haiyan;ZHANG Min;GUAN Shufen;GAO Xue;The First Affiliated Hospital of Qiqihar Medical College;;Influence of clinical nursing pathway on self-management abilities of patients with asthma[J];中国现代医生;2015-05
3 WANG Hai-rong;Worker's Hospital of Xuangang Company of Iron and Steel Group in Hebei Province;;Effect of methylprednisolone on serum IL-18 and IL-33 levels in patients with asthma[J];海南医学院学报;2015-02
4 Zhang Yu'e;Wei Lin;Shan Beilan;Xu Fei;Shuai Ruixue;Xu Jiao;Li Hong;Rong Hua;Department of Pediatrics,the Liqun Hospital of Putuo District;;Clinical study of serum immunoglobulin E,immunoglobulin G_4 and leukotriene B4 levels in children with acute asthma[J];中华实用儿科临床杂志;2014-21
5 ZHANG Huan-yu;YANG Li-yan;Emergency Department,Beiche Hospital;;Observation of clinical curative effect of leukotriene antagonist combined with corticosteroids inhalation in the treatment of chronic moderate persistent bronchial asthma[J];临床肺科杂志;2014-07
6 SUN Bo-wen;TANG Ying;LI Xiao-dan;XU Li-jun;Department of Respiratory Medicine,First Hospital,Jilin University;;Detection of IL-33 levels in peripheral blood of patients with bronchial asthma and its role in pathogenesis of bronchial asthma[J];吉林大学学报(医学版);2014-02
7 LIU Shu-ping,MA Ran,LI Xiang-an.Department of Pediatrics Medicine,People's Hospital of Jinxiang City,Jinxiang 272200,China;The relationship between interleukin 33 promotes and lung inflammation in asthmatic children[J];疑难病杂志;2013-06
【Citations】
Chinese Journal Full-text Database 3 Hits
1 WANG Xin,MA Chun-yan,ZHANG Ya-jing,NING Li-hua,CHEN Hua,ZHOU Fang,HAO Jin-li,ZHOU Rui(Department of Pediatrics,the Third Affiliated Hospital of Inner Mongolian Medical College,Baotou 014010,Inner Mongolian Autonomous Region,China);Expressions of Serum Interleukin-17 and Leukotriene B4 in Childhood Asthma and Their Clinical Significance[J];实用儿科临床杂志;2012-04
2 WU Su-ling1,CHU Wei-hong2,PENG Shao3;Significance of Change on Serum Interleukin-17 Level in Children with Asthma[J];实用儿科临床杂志;2010-18
3 RAO Lufei1,ZHU Xiaoping1,ZHOU Zhijiang2,CHENG Ping3(1.Department of Pediatrics,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China;2.Guiyang Children's Hospital,Guiyang 550003,Guizhou,China;3.Department of Immunology,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China);A Preliminary Study on Determination of Serum IL-17 Levels of Children with Asthma[J];贵阳医学院学报;2010-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Yu Shanshan;Xu Yanrong;Department of Pediatrics,the Second People's Hospital of Yuyao;;Observation of montelukast sodium in the treatment of children with cough variant asthma[J];中国基层医药;2016-15
2 Wang Dan;Wu Wei;Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Xi'an Medical University;;Mechanism of novel anti-inflammatory mediator resolvin E1 in bronchial asthma[J];国际呼吸杂志;2016-12
3 Han Jichang;Qi Guanbin;Liu Xiaochun;Yang Cunbao;Chen Na;Li Hongbing;Zhang Yijie;Department of Respiratory Medicine,Huaihe Hospital of Henan University;;Expressions of IL-21 and activating transcription factor 3 in lung tissue of patients with chronic asthma[J];国际呼吸杂志;2016-07
4 ZHANG Ya-mei;WANG Ju-fang;LI Li;Department of Pediatrics,Guangyuan Maternal and Child Care Service Center;;Change and significance of Th17 / IL-17 in peripheral blood of patients with acute asthma[J];临床肺科杂志;2015-11
5 LI Ran;ZHANG Jie;QIAO San-fu;Department of Pediatrics,Chengde County Hospital;Department of Geriatrics,Chengde Central Hospital;;The impact of combined aerosol inhalation of budesonide and salbutamol on the levels of IL-17 and IL-25 in children with acute asthma[J];临床和实验医学杂志;2015-04
6 Zhang Yu'e;Wei Lin;Shan Beilan;Xu Fei;Shuai Ruixue;Xu Jiao;Li Hong;Rong Hua;Department of Pediatrics,the Liqun Hospital of Putuo District;;Clinical study of serum immunoglobulin E,immunoglobulin G_4 and leukotriene B4 levels in children with acute asthma[J];中华实用儿科临床杂志;2014-21
7 Wu Xiaoman;Lu Xiaoxia;Zhang Zhi;Department of Pediatrics,Wuhan PuAi Hospital;;Effect of T cell immunoglobulin domain and mucin domain protein-3 gene interfered by short hairpin RNA on helper T lymphocytes 17 differentiation and proinflammatory capacity in asthmatic mice[J];中华实用儿科临床杂志;2014-04
8 XU Qing;The Affiliated Hospital of Guilin Medical University;;Toll like receptors 4(TLR4)and airway smooth muscle cells[J];华夏医学;2014-01
9 Wang Xuesong;Pan Jiahua;Department of Pediatrics,Anhui Provincial Hospital Affiliated to Anhui Medical University;;Current research development of neutrophil extracellular traps[J];中华实用儿科临床杂志;2014-03
10 YU Wen-kai;WEN Shu;Department of Microecology,Dalian Medical Univorsity;;Gut microbiota and allergic asthma[J];中国微生态学杂志;2013-10
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 MA Xusheng;TU Linxiu;MEI Yijun;BI Haiyan;YU Shengbo;WANG Huijie;WANG Caifu;CHEN Zhimin;The People's Hospital of Ningbo Beilun;The Children's Hospital Affiliated to Zhejiang University School of Medicine;;Treatment efficacy evaluation of standardized management for children with asthma[J];临床儿科杂志;2015-08
2 GENG Hai-Yun;CAO Li;WANG Wei;CHEN Da-Kun;CHEN Chao-Ying;CHU Mei;JI Li-Na;WANG Jing-Jing;TU Juan;LI Jian-Guo;LI Hua-Rong;DU Pei-Wei;Department of Nephrology, Capital Institute of Pediatrics;;A prospective, randomized, controlled clinical study of Huai Qi Huang granules in treatment of childhood primary nephrotic syndrome[J];中国当代儿科杂志;2015-01
3 ZHANG Shu-lin;CUI Lan-wei;Department of Pediatrics,the First Affiliated Hospital of Harbin Medical University;;Research Progress on Huai'er and Its Compound Preparation Huai-qi-huang Granule[J];医学综述;2015-01
4 JING Xiao-ping;CHEN Wen-xia;Shanghai Children's Hospital Affiliated to Shanghai Jiao Tong University;The First Hospital Affiliated to Henan College of Traditional Chinese Medicine;;Clinical Study of “Huaiqihuang Granule”for Preventing Recurrent Respiratory Infections in Children with Bronchial Asthma[J];上海中医药大学学报;2014-03
5 SUN Bo-wen;TANG Ying;LI Xiao-dan;XU Li-jun;Department of Respiratory Medicine,First Hospital,Jilin University;;Detection of IL-33 levels in peripheral blood of patients with bronchial asthma and its role in pathogenesis of bronchial asthma[J];吉林大学学报(医学版);2014-02
6 Guo Yanyan;Affiliated Hospital of Inner Mongolia Medical University;;Clinical Effects of Huaiqihuang Particle Combined with Montelukast Sodiumin Treated Children with Cough Variant Asthma[J];儿科药学杂志;2014-03
7 KONG Xiao-mei;HAN Bao-fen;ZHANG Cai-ping;CAO Da-wei;LI Ai-min;WU Shi-man;The First Hospital of Shanxi Medical University;;Etiological characteristics of bronchial asthma of acute exacerbation[J];中华医院感染学杂志;2014-01
8 ZHOU Guo-zhong;SHEN Ju-xin;WANG Hao-sheng;QIN E;SUN He;DONG Xue-junShaoxing;People’s Hospital,Shaoxing Hospital of Zhejiang University,Clinical Laboratory Center;;Clinical significance of measurement of changes in EBC leukotriene C4,8-isoprostane and nitrate levels in intermittent and persistent asthma patients[J];中华哮喘杂志(电子版);2013-05
9 The National Cooperative Group on Childhood Asthma;Institute of Environmental Health and Related Product Safety,Chinese Center for Disease Control and Prevention;;Third nationwide survey of childhood asthma in urban areas of China[J];中华儿科杂志;2013-10
10 SUN Yan-zhen;YUAN Xue-jing;SUN Yi-qiu;The First Medical College,Nanjing University of Chinese Medicine;The Affiliate Hospital of Nanjing University of Chinese Medicine;;Research on Immunological Mechanisms and Regulation of Traditional Chinese Medicine in Asthma[J];南京中医药大学学报;2013-05
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Si Shangfen;Department of Respiratory Medicine,Dengzhou People's Hospital;;Influence of trinity nursing mode on disease uncertainty and survival quality in patients with asthma[J];国际医药卫生导报;2016-18
2 Yaqng Feifei;Yu Yiguang;Wang Kun;Zhang Haidong;Wang Hui;Wang Rui;Yi Jihu;Shandong Academy of Occupational Health and Occupational Medicine Shandong Institude of Prevention and Control of Occupational Health and Occupational Disease;Shandong Academy of Medical Sciences;;Effect of formaldehyde exposure on the level of cytokines in human bronchial epitheial 16HBE cells[J];中华劳动卫生职业病杂志;2016-01
3 Xu Wei;Xiang Li;Shen Kunling;Department of Pediatric Allergy,Beijing Children's Hospital Affiliated to Capital Medical University;;Clinical features of moderate to severe asthma exacerbation in school-age children[J];中华实用儿科临床杂志;2015-21
4 FU Xiaoyun;SHI Jing;Department of Pediatrics, the No.6 People's Hospital of Longgang District;;Study on the Changes of Serum Total Immunoglobulin E and Specific Immunoglobulin E in Children with Asthmatic Disease[J];临床医学工程;2015-10
5 CAO Wei-qiang;LI Zu-yong;SU Jin-zhong;Emergency Department,People's Hospital of Taishan City;Emergency department,Sun yat-sen Memorial Hospital of Guangzhou City;;Involvement of extracellular matrix remodeling and up-regulated TNF-αin asthma rat and the interventions of montelukast sodium[J];海南医学院学报;2015-09
6 CHEN Fan;JIAO Lin;WU Sha;HU Jia-hao;YANG Jiong;Zhongnan Hospital Affiliated to Wuhan University;;Clinical observation of montelukast combined with antibiotics in the treatment of bronchiectasis[J];临床肺科杂志;2015-09
7 WAN Hua-lin;ZHOU Yu-zhen;DAI Xin-jian;People's Hospital of Yongjia County;Department of Respiratory Diseases,Wenzhou Center Hospital;;Efficacy and safety of doxofylline combined with combivent against acute exacerbation of bronchial asthma in 60 patients[J];中国医院药学杂志;2015-16
8 DENG Chunyou;XIE Zhiheng;ZHANG Junling;ZENG Shuyuan;LI Youqiong;Boluo People's Hospital;;Influence of continuous self-management education on disease self-management ability of patients with interventional treatment of coronary heart disease[J];中国医药科学;2015-13
9 LIN Mao-hua;WANG Zhi-hui;TANG Yu-qing;Department of Respiratory Medicine, People's Hospital of Boluo County;;Changes and Clinical Significance of Serum TNF- α Level in Patients with Refractory Asthma[J];实用心脑肺血管病杂志;2015-06
10 CHEN Xuyang;ZHANG Bing;HU Liman;Department of Pediatrics, the People's Hospital of Leqing City,Zhejiang Province;;IL-17, IL-33 role in the pathogenesis of asthma[J];中国医药导报;2015-16
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 WU Su-ling1,CHU Wei-hong2,PENG Shao3;Significance of Change on Serum Interleukin-17 Level in Children with Asthma[J];实用儿科临床杂志;2010-18
2 Zhu Yan Department of Internal Medicine,Respiratory Section,Lishui Municipal People's Hospital,Lishui(323000),China;Study on the Significance of Changes of Plasma IL-13,LTB-4,MMP-9,TIMP-1 Levels in Patients with Asthma[J];放射免疫学杂志;2010-04
3 SHI Yu-Heng,SHI Guo-Chao,WAN Huan-Ying,JIANG Li-Hua,AI Xiang-Yan,ZHU Hai-Xing,TANG Wei.Department of Respiratory Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;The prevalence of blood Th17 and CD4~+CD25~+Treg cells in patients with bronchial asthma[J];中国免疫学杂志;2010-08
4 LI Jing,TAN Wei-ping,WU Bao-jing,LAN Dan,LI Wen-yi,MAI Xian-di,FAN Ling-ling (Department of Pediatrics,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China);Relationship between Interleukin-17 and Neutrophil Inflammation Reaction in Children with Moderate to Severe Asthma[J];中山大学学报(医学科学版);2010-04
5 ZHOU Chen, YIN Kai-sheng, CHEN Jun-hao1, SHI Ying (Department of Respiratory Medicine,the First Affiliated Hospital of NJMU,Nanjing 210029; 1Clinical Test Center,Drum Tower Hospital Affiliated to Medical School of Nanjing University,Nanjing 210008,China);Changes of the ratio of T helper 17 cells and the level of IL-17 in bronchial asthmatic mice[J];南京医科大学学报(自然科学版);2009-08
6 ZHANG Chao-yong,LI Ling-mei(Department of Pediatrics,the General Hospital of Pangang,Panzhihua 617023,China);Effect of atomization inhalation with salbutamol to treat acute episode of bronchial asthma on child[J];新乡医学院学报;2009-04
7 WANG Shi-ying1,HU Xin-gang2,WU Chun-fang1,et al(1.Department of Internal Medicine,Huaihe Hospital of Henan University,Kaifeng 475000,China;2.Department of Respiratory Medicine,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China);Serum immune globulin E and interleukin-8 in bronchoalveolar lavage fluid of bronchial asthma patients[J];新乡医学院学报;2009-01
8 LI Ming-xin, LU Chang-long (Department of Immunity, Basic Medical College, China Medical University, Shenyang 110001, China);IL-17,IL-25 serum levels of asthma patients[J];中国医药导报;2008-22
9 WANG Hong-wei1,QU Shu-qiang1,GAO Jun2,ZHANG Feng-xia1(1.Department of Pediatrics,the Fifth Affiliated Hospital of Haerbin Medical University,Daqing 163316,China;2.Department of Pedia-trics,the Second Affiliated Hospital of Haerbin Medical University,Haerbin 150001,China);Significance of Determining Interleukin-17,Matrix Metalloproteinases-9 and Immunoglobulin E in Serum of Asthmatic Children[J];实用儿科临床杂志;2007-04
10 SHEN Feng, ZHAO Ming wu, HE Bei, WANG Yu zhu, YAO Wan zhen. Department of Respiratory Medicine, Third Hospital, Peking University, Beijing 100083, China;The levels and clinical implications of induced sputum interleukin 17 in chronic obstructive pulmonary disease and asthma[J];中华内科杂志;2004-12
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved