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《Chinese Journal of Difficult and Complicated Cases》 2014-03
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Effects of trimetazidine combined with levothyroxine on the cardiac function in the patients with hypothyroid heart disease

GUO Wei;ZHANG Fan;LI Yang;LENG Qin;Department of Endocrinology,Wuhan First Hospital;  
Objective To explore the effects of trinietazidine combined with levothyroxine on the cardiac function in the patients with hypothyroid heart disease.Methods 84 cases of hypothyroidism heart disease were randomly divided into two groups;42 cases in the observation group,used of trinietazidine and levothyroxine sodium for therapy;42 cases in the control group,used of levothyroxine sodium for therapy.2 groups at baseline,after 2 months of treatment,thyroid function(FT_3,FT4,TSH),left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular systolic diameter(LVESD),and 6 min walking distance were tested,evaluate the therapeutic effect.Results After treatment,the total effective rate of observation group was 88.10%(37/42) which is higher than 59.52%(25/42) in control group,the difference was statistically significant(P 0.05);compared with before treatment,2 groups' FT_3,FT_4,TSH,LVEF,LVEDD,LVESD and 6 min walk distance were significantly improved after treatment(P 0.05),and the more obvious improvements in the observation group(P 0.05) was found.Conclusion Trinietazidine combined with levothyroxine in the patients with hypothyroid heart disease can significantly improve the cardiac function,shorten the period of treatment,which is safe and effective.
【CateGory Index】: R541.8
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