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《Chinese Journal of Difficult and Complicated Cases》 2014-07
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Effects of Yiqihuayutongluo decoction on blood coagulation and blood lipid in patients with primary nephrotic syndrome in hormone maintenance stage

BIAN Dong;LV Zhe;SHI Meng;WANG Xinai;GUO Dengzhou;Department of Nephrology,Hebei Province Hospital of TCM,Hebei Province;  
Objective To observe the effect of Yiqihuayutongluo decoction on primary nephrotic syndrome hormone maintain influence treatment and coagulation function in patients with blood lipid phase.Methods Fifty patients who had been diagnosed with primary nephrotic syndrome and received maintained treatment of hormone were randomly divided into two groups,25 cases in the treatment group were given Yiqihuayutongluo decoction combined hormone therapy,25 cases in the control group were treated with hormone therapy,2 groups received 1 months of continuous treatment,and then observe blood coagulation,blood lipid and blood and urine protein index.Results In treatment group,compared before and after treatment,it has significant difference in reducing plasma fibrinogen(Fib),increase of antithrombin III(AT-III),lower serum total cholesterol(TC),triglyceride(three TG),low density lipoprotein cholesterol(LDL-C) and reduce 24 h urine protein(24h UP),elevated serum albumin(Alb)(P 0.01);while the control group after treatment,all indexes were not significant improvement.Treatment group and control group after treatment,treatment group has more significant effect in reducing plasma Fib,increased AT-III,reduce serum TC,TG and reduce 24 h UP(P 0.05 or P 0.01).Conclusion It proved that the Yiqihuayutongluo decoction could obviously improve the blood hypercoagulability and disorders of lipid metabolism in patients with the primary nephrotic syndrome in treatment of hormone maintain stage.
【Fund】: 河北省科学技术研究与发展计划项目(No.09276418D-19)
【CateGory Index】: R277.5
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