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《Chinese Journal of Difficult and Complicated Cases》 2016-11
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Clinical effect of BiPAP noninvasive ventilation combined with terbutaline and ambroxol in severe COPD patients

Jiaerken·lasibai;LAN Qiuyan;LI Junmei;Department of Respiratory Medicine,the 474 Hospital of PLA;  
Objective To observe the clinical effect of severe chronic obstructive pulmonary disease(COPD) patients treated by BiPAP noninvasive ventilation combined with terbulaline and ambroxol.Methods From June 2014 to 2015 October,100 patients of severe COPD from PLA 474 hospital were enrolled as object of observation.They divided into noninvasive ventilation group(45 case) and Combined treatment group(55 case),noninvasive ventilation group treated by BiPAP noninvasive ventilation,Combined treatment group treated by BiPAP noninvasive ventilation combined with terbutaline and ambroxol.Clinical effect by Pulmonary function,blood gas indexes and serum inflammatory cytokines levels before and after treatment,adverse reaction conditions were observed.Results The total effective rate in observation group was significantly higher than the control group(98.2%vs.84.4%,χ~2=6.346,P=0.012);the indexes of lung function before treatment in2 groups of 6 minute walk test(6MWT),forced vital capacity(FVC),forced expiratory volume in one second(FEV_1),FEV_1/FVC,maximal mid-expiratory flow(MMEF) and the peak expiratory How rate(PEF) had no statistical significance of PaO_2,pH and blood gas index and PaCO,level difference(P0.05).Alter treatnienl,the 2 groups of patients with lung function index and PaO_2 and pH were higher than that before treatment,PaCO_2 was lower than before treatment,and the observation group changed more obviously than that in control group(P0.05);before treatment,no significant difference between the 2 groups of patients with IL-8,1L-17,hs-CRP,TNF-α index(P 0.05).After treatment,the indexes of the 2groups of patients were lower than that before treatment,and the observation group decreased more obvious than the control group(P0.05).No adverse reactions occurred in 2 groups of patients.Conclusion BiPAP noninvasive ventilation combined with terbutaline and ambroxol has better therapeutic effect in the treatment of severe COPD patients,can significantly improve the patients lung function and blood gas levels.
【Fund】: 新疆维吾尔族自治区科技支疆(指令性)项目(201491121)
【CateGory Index】: R563.9
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