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《Chinese Journal of Difficult and Complicated Cases》 2018-05
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Correlation between the changes of lipid metabolism and the incidence of gestational diabetes

WANG Wei;HUANG Xingquan;JIANG Lanye;LI Xiufen;FENG Jingru;Department of Endocrinology,Second Affiliated Hospital of Hebei North University;Department of Obstetrics and Gynecology,Second Affiliated Hospital of Hebei North University;  
Objective To observe the level of lipid metabolism in patients with gestational diabetes and to explore the correlation with the onset of gestational diabetes. Methods Pregnant women with gestational diabetes treated in department of endocrinology of Second Affiliated Hospital of Hebei North University from February 2016 to June 2017 were selected as the research objects(60 cases),and the healthy pregnant women who received the antenatal examination were selected as the control group(60 cases). The differences of lipid metabolism,blood glucose level and cytokine levels between the two groups were observed,and the correlation among lipid metabolism,blood glucose level and cytokine levels in gestational diabetes mellitus was analyzed. Results The levels of TC,LDL-C,TG and visfatin in the observation group were higher than those in the control group( t =-7. 516,t =-5. 323,t =-14. 787,t =-86. 705,all P 0. 001),and the levels of HDL-C and adiponectin were lower than those in the control group( t = 16. 378,t = 9. 712,P 0. 001); The levels of MBG,SDBG,NEGE,FPG and HbA_(1c)in the observation group were higher than those of the control group( t =-23. 372,t =-5. 829,t =-5. 702,t =-14. 407,t =-14. 147,P 0. 001); The levels of CRP,IL-6 and TNF-alpha in the observation group were higher than those in the control group( t =-17. 384,t =-10. 295,t =-14. 072,P 0. 001); The levels of TC,LDL-C,TG and visfatin in gestational diabetes mellitus were positively correlated with MBG,SDBG,NEGE,FBP,HbA_(1c),CRP,IL-6 and TNFalpha level. Conclusion The TC,LDL-C and other lipid metabolism indexes are higher in gestational diabetes mellitus patients,and are closely related to blood glucose levels and cytokines levels,which can be used as an important index for clinical monitoring of the onset of gestational diabetes.
【Fund】: 河北省科技支撑计划项目(152777232)
【CateGory Index】: R714.256
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