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《Journal of Yunnan University (Natural Sciences)》 2004-04
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High throuphput screening of bioactive substances from actinomycetes

JIANG Yi~1, DU Guan-hua~2, SUN Qiu~1, PENG Yun-xia~(1,3), LI Ling-feng~(1,3), XU Li-hua~1robial Resources ofMinistry of Education,P.R.China,Kunming 650091,China;2.Chinese Academy of Medical Sciences,Beijing 100730,China;3.Quarantine Bureau of Yunnan Province,Kunming 650031,China)  
Actinomycetes are one of important microbial resources producing bioactive metabolites.2?600 actinomycete strains were isolated from soil samples collected from Yunnan.Each strain was fermented and extracted,and 2?600 extracts were obtained.These extracts were selected by using 4 models in vitro with High Through Screening system.Results of screening indicate that 0.4% strains have anti-oxidation,and 2.7%,(0.34%) and 0.3% of strains have inhibitions against AchE,NOS,and AGE respectively.Inhibition of strain YIM 32766 against AchE was 108.3%.Inhibition of one of elements of extracts of strain YIM 30243 against NOS was 151.8%.Inhibition of strain YIM32012,YIM32215,YIM32234,YIM32212,YIM32044 and YIM32025 against AGE were 300.66%,42.16%,133.94%,122.59%,110% and 101.71% respectively.These strains with high bioactivity should have potential value for future development of drug.
【Fund】: 科技部基础研究重大项目前期研究专项(2001CCC00600).
【CateGory Index】: Q936
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