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《Tropical Agricultural Science & Technology》 2012-04
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Study on Hypoglycemic Effect of Synsepalum dulcificum and Its Mixtures in Alloxan-induced Diabetic Mice

GUO Gang-jun1,YUAN Zhi-zhang1,ZHANG Xue-hui2,YANG Yan1,WANG Rui-xin2,YANG Xi-liang2,YANG Yun-zhi2,YIN Jian-zhong2* 1.Yunnan Institute of Tropical Crops,Jinghong 666100,China;2.Research Institute of Nutrition and Food Science,Kunming Medical University,Kunming 650500,China  
Animal model of diabetes was established by injecting alloxan into mice abdominalcavity,Synsepalum dulcificum and Synsepalum dulcificum-Angelica keiskei mixture were lavaged into stomachs by 0.2 mL(/ 10g.d)with 26 days standing.The effect on body weight and blood glucose was then observed in alloxan-induced diabetic mice.The results indicated that body weight of mice of control groups and dose groups significantly increased and there were no significant differences in body weight of all groups mice after lavaging stomachs.Comparing the model group,the groups in low,medium and high doses of Synsepalum dulcificum and its mixtures could significanly decrease blood glucose level.Hypoglycemic effects of Synsepalum dulcificum low and high dose groups showed the better and closed to metformin,but Synsepalum dulcificum and Synsepalum dulcificum-Angelica keiskei mixture had no dose-response relationship on hypoglycemic effects.
【Fund】: 西双版纳州发展和改革委员会傣药南药办项目
【CateGory Index】: S667.9
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