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《Chinese Journal of Conservative Dentistry》 2009-06
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Treatment of periodontal defect with combination of GTR,CPC and bFGF:An experimental study in rabbits

ZHU Jian-hua,WANG Ying,QU Xiao-juan(College of Oral Medicine,Jia Mu Si University Heilongjiang,Jiamusi 154002,China)  
AIM: To evaluate the effectiveness of combined use of rh-bFGF,CPC and medical collagen membrane compounds on regeneration of the rabbit periodontal tissue.METHODS: Sixteen rabbits were selected and bone defect of 3.5mm×2.5mm×2mm in "U" size was created in the distal area of the bilateral middle incisors of the mandible.As to the restoration methods,rh-bFGF and CPC compounds were implanted in the bone defect area in the group 1 and only the CPC was implanted in the group 2,which were both overlaid with the collagen membrane.There was only collagen membrane overlaying in the bone defect area in the control group.The therapeutic results were evaluated by clinical and imaging examination as well as histological index.SPSS13.0 software package was used for ANOVA.RESULTS: 8 weeks after operation,there were various amounts of newly formed alveolar bone,cement and connective tissues in the dental defect of "U" size in all three groups.There was significant difference in alveolar osteogenesis between the control group and the 2 experimental groups.The difference was also significant between the two experimental groups(P﹤0.01).CONCLUSION: Application of rh-bFGF/CPC compounds is beneficial to the regeneration of the alveolar bone and avoid the side effects such as root resorption and bone malunion,which often occur after the conventional periodontal regenerative therapy.
【Fund】: 大连市科技计划项目(2004B3SF152)
【CateGory Index】: R782
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【Citations】
Chinese Journal Full-text Database 6 Hits
1 CHENG Ge,JIANG Dian ming (Department of Orthopaedic,First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China);Progress in studies of calcium phosphate cement[J];Journal of Traumatic Surgery;2002-S1
2 ZHENG Lei WANG Qian WEI Kuan-hai Pei Guo-xian (Department of Orthopedics and Traumatology. Clinical Laboratory Nanfang Hospital, First Military Medical University. Guangzhou 510515. China);Biological effects of basic fibroblast growth factor on bone marrow stromal cells[J];JOURNAL OF FIRST MILITARY MEDICAL UNIVERSITY;2000-02
3 WU Yong,WU Zhi-fen,WANG Qin-tao, et al ( College of Stomatology,The Fourth Military Medical University, Xi'an 710032,China );The combining effects of recombinant human bone morphogenetic protein-2 and basic fibroblast growth factor on the proliferation of human periodontal ligament cells[J];Chinese Journal of Conservative Dentistry;2001-01
4 SANG Hong-xun,YANG Ke-qiang,WANG Zhen,et al.Institute of Orthopaedics,Xijing Hospital,the Fourth Military Medical University,Xian 710032;Repair of large segmental femur defects in rabbits with massive allograft combined with BMP and CPC[J];Orthopedic Journal of China;2006-01
5 Wang Wenbo 2, Chen Zhongwei 1, Chen Tongyi 1, Ye Shunhua 3, Song Jian 3, Zhang Shuxun 4(1 Department of Orthopedics, Zhong shan Hospital, Fudan University, Shanghai 200032) (2 Department of Orthopedics, 1st Affiliated Hospital, Harbin Medical Unive;EXPERIMENTAL STUDY ON BIOLOGICAL COMPATIBILITY OF CALCIUM PHOSPHATE CEMENT (CPC) ASAN ARTIFICIAL BONE MATERIAL[J];Chinese Journal of Biomedical Engineering;2001-03
6 DAI Hong-lian 1, YAN Yu-hua 1, CAO Xian-ying 1, LI Shi-pu 1, HE Jian-hua 1, YU Guo-rong 2 (1. Biomedical Materials and Engineering Center, Wuhan University of Technology, Wuhan 430070, China; 2. Zhongnan Hospital, Wuhan University, Wuhan 430072, China);Biocompatibility of calcium phosphate bone cement[J];The Chinese Journal of Nonferrous Metals;2002-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 FAN Donghui XU Zheng LI Shipu YAN Yuhua CHEN Xiaoming ( Microelectronic Materials Institute,Department of Materials Science and Engineering,Tongji University, Shanghai 200092; Biomaterials Research Centre,Wuhan University of Technology,Wuhan 430070);Fabrication of Porous β-TCP Biomaterials by Sponge-soaking Process[J];Materials Review;2003-04
2 HUANG Qi RUAN Ziwei LI Dongxu (Materials Science and Engineering,College of Nanjing University of Technology,Nanjing 210009);Biological Properties of Calcium Phosphate Cement[J];Materials Review;2005-07
3 ZHENGLei 1 ,WANGQian 1 ,PEIGuo-xian 2 ,MA Jian-biao 3 ,WANGYi-nong 3 ,WANGXiao-hong 3 Departmentof LaboratoryDiagnosis 1 ,Departmentof TraumatologyandOrthopedics 2 ,NanfangHospital,First MilitaryMedicalUnive;A morphological study of the cellular biocompatability of a new bone-matrix material in vitro[J];Journal of First Military Medical University;2002-01
4 HE Quan-min, LIU Jian-guo, XU Ruo-zhu, ZHANG Jian, FAN Qin, JIANG Ce Affiliated Stomatological Hospital of Zunyi Medical College, Zunyi 563003, China;Effect of tea polyphenols on proliferation of human periodontal ligament fibroblasts[J];Journal of Southern Medical University;2008-08
5 LIU Lan-ning~1,ZHANG Shi-hua~2,WANG Zhen~3.(1.Department of Special Course,the south Campus of Southern University,Guangzhou 510315;2.Zhujiang hospital of Nanfang Medical University,Guangzhou 510282;3.Department of Stomatology,the 94 Hospital of Nanchang,Nanchang 330002,China);The effects of enamel matrix proteins and bone morphogenetic protein 2 on cell proliferation by cultured human periodontal ligament cells[J];Journal of Branch Campus of the First Military Medical;2005-02
6 FENG Ping, LIU Qi, GAO Li, et al. Department of Oral Medicine, Faculty of Stomatology, Zunyi Medical College, Zunyi 563003;The Effects of Transforming Growth Factor-β_1 and Basic Fibroblast Growth Factor on the Proliferation of Human Pe(riodontal) Ligament Fibroblasts[J];Journal of Dental Prevention and Treatment;2005-04
7 ZHANG Li,LI Yu-bao,Lü Guo-yu,SHI Pu-jiang(Analytical & Testing Center,Research Center for Nano-biomaterials,Sichuan University,Chengdu 610064,China);Effects of zinc oxide on the physico-chemical properties of n-HA/chitosan cement[J];Journal of Functional Materials;2006-12
8 WANG Ying1, QU Xiao-juan2.(1. Dept. of Oral Medicine, College of Stomatology, Jiamusi University, Jiamusi 154004, China;2. Dept. of Oral Medicine, College of Stomatology, Medical of Dalian University, Dalian 116622, China);The application of regeneration of guided tissue and guided bone as well as its growth factors into periodontal osseous defects[J];International Journal of Stomatology;2008-06
9 TU Xiao li (Department of Stomotology,NanFang Hospital,First Military Medical University,Guangzhou 510515,China);Growth factors and periodontal tissue engineering[J];Foreign Medical Sciences Biomedical Engineering;2002-02
10 KANG Kai ,ZHANG Qi-qing . Institute of Biomedical Engineering ,China Academy of Medical Science and Peking Union Medical College,Tianjin 300192,China;Progress in carrier for growth factor controlled release in tissue engineering[J];;2005-06
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 SANG Hong Xun 1, HU Yun Yu 1, LI Dan 1, DAI Xiu Lan 2, LU Rong 1, YANG Guang 1, SUN Yi Qun 2 1Institute of Orthopedics of Chinese PLA, 2Department of Clinical Laboratories, Xijing Hospital, Fourth Military Medical University, Xi'an;Sterilization of bio-active bone graft[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-01
2 Zhou Xulong 1 Deng Yiping 2 1 (Dept.of Pathology;Medical College of Jinan University,Guangzhou 510632) 2 (Dept.of Histology and Embryology,Sun Yat Sen University of Medical Sciences,Guangzhou 510089);The Influence of Basic Fibroblast Growth Factor on the Adherence of Endothelial Cell to Polyurethane[J];JOURNAL OF BIOMEDICAL ENGINEERING;1998-03
3 Wang Wenbo Chen Zhongwei Chen Tongyi (Department of Othopaedics,1 st Clinical Hospital,Harbin Medical University,Harbin 150001);Latest Progress in Studies of Self-Setting Calcium Phosphate Cement[J];JOURNAL OF BIOMEDICAL ENGINEERING;2000-01
4 Wang Qintao, Shi Junnan, Wu Zhifen et al School of Stomatology, The Fourth Military Medical University(710032);The effects of bone morphogenetic protein on the proliferation and alkaline phosphatase activity of periodontal ligament cell[J];CHINESE JOURNAL OF CONSERVATIVE DENTISTRY;1996-03
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