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《CHINESE JOURNAL OF CONSERVATIVE DENTISTRY》 1999-01
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Effect of recombinant human Insulin-like growth factor-I and recombinant human bone morphogenetic protein-2 on proliferation of human periodontal ligament cells

Liu Hong, Wu Zhifen, Wang Qintao School of Stomatology, The Fourth Military Medical University, Xi'an 710032  
Aim: To study the effect of recombinant human Insulin-like growth factor-I and recombinant human bone morphogenetic protein-2 on human periodontal ligament cells proliferation. Methods: Human periodontal ligament cells were cultured by tissue explant and its proliferation were mesured by MTT colorimetric assay. Results: rhIGF-I or rhBMP-2 can stimulate human PDL cells proliferation in dose-dependent manner. The co-ordinate use of rhIGF-I and rhBMP-2 has synergetic effect on PDL cells proliferation. Conclusions: rhIGF-I and rhBMP-2 can be used as bioactive mediator on periodontal regeneration.
【Fund】: 国家自然科学基金
【CateGory Index】: R780.2
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