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《Chinese Journal of Pharmaceutical Analysis》 2004-01
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HPLC Determination of Cinnamic Acid in Human Plasma

CI Lei,TANG Xing and HE Zhong -gui (Division of Pharmaceutics, College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016)  
Objective: To develop a method for the quantitative determination of cinnamic acid in human plasma. Methods: HPLC method and Hypersil ODS column ( 200 mm×4. 6 mm, 5μm) were used, the mobile phase was acetonitrile -0. 1 mol·L-1 KH2PO4 solution (30: 70) , at a flow rate of 1. 2 mL ·min-1 ,the UV detection wavelength was 272 nm,3 - (3 - methylphenyloxy) propanoic acid was used as internal standard. Results:The recovery of the method was 104. 9% , the recovery of the extraction was 86. 6% . The within - day precision and the day - to -day precision were both lower than 7. 0% . Conclusion: The method is sensitive,specific,accurate and precise, and is appropriate for the determination of cinnamic acid.
【CateGory Index】: R285
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