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《Chinese Journal of Pharmaceutical Analysis》 2005-07
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Determination of the Antiviral Caffeoyl Quinic Acids Isolated from Lonicera japonica Thunb.

MA Shuang - cheng, Paul BUT Pui - Hay, Vincent OOI Eng - Chun, Spencer Hon - Sun LEE , Song - Fong LEE (National Institute for the Control of Pharmaceutical & Biological Products,Beijing 100050,China; Department of Biology and Institute of Chinese Medicine,The Chinese University of Hong Kong,Shatin,Hong Kong,China; Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada)  
Objective:To search for the antiviral components from the flowers of Lonicera japonica Thunb. (Jin-Yin-Hua) and determine the contents of these compounds. Methods:To isolate components in various column chromatography and test the antiviral activities in CPE methods. The contents were determined by RP - HPLC methods. Results:13 Caffeoyl quinic acids,caffeic acid and caffeic acid methyl ester were isolated from Jin - Yin - Hua. These caffeoyl quinic acids showed antiviral activities against respiratory viruses. The contents of 6 caffeoyl quinic acids and caffeic acid were determined by RP - HPLC. Conclusion:The caffeoyl quinic acids are the effective components in Jin - Yin - Hua. This method is simple and accurate.
【Fund】: 国家科技部创新药物和中药现代化及香港Industrial Support Fund AF/281/97资助课题
【CateGory Index】: R284
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