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《Chinese Journal of Pharmaceutical Analysis》 2012-09
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HPLC method for simultaneous determination of three caffeoylquinic acids in Laiyang pear clear paste

GUI Yi1,XU Li-hua2,LIN Yong-qiang2(1.Beijing North Hospital,Beijing 100089,China;2.Shandong Institute for Food and Drug Control,Jinan 250101,China)  
Objective:To develop an HPLC method for simultaneously determination of three caffeoylquinic acids(3-O-caffeoylquinic acid,chlorogenic acid,4-O-caffeoylquinic acid)in Laiyang pear clear paste.Methods:Thermo BDS(4.6 mm×250 mm,5 μm)column was adopted.The mobile phase consisting of acetonitrile(A)-0.4% phosphoric acid solution(B)with gradient elution(0-35 min,5%A→10%A;35-40 min,10%A)was applied at a flow rate of 1.0 mL·min-1.The detection wavelength was 327 nm.Results:The calibration curves were linear in the ranges of 0.023-0.230,0.022-0.224,0.023-0.226 μg for 3-O-caffeoylquinic acid,chlorogenic acid(5-O-caffeoylquinic acid),4-O-caffeoylquinic acid;The average recoveries(n=6)were 97.2%,97.0% and 99.5%,respectively.Conclusion:The method is simple,accurate,and sensitive,which can be used for quality control of multi-component in Laiyang pear clear paste.
【CateGory Index】: R286.0
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【Citations】
Chinese Journal Full-text Database 3 Hits
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 SHEN Zhi1,ZHANG Wen-ting2,HUA Yun-fei1,ZHAO Wei-liang2 1.College of Pharmacy,Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,China 2.Zhejiang Institute for Food and Drug Control,Hangzhou 310004,China;Fingerprinting Analysis of Four Variants of Chrysanthemi Morifoli Flos by RP-HPLC[J];中草药(英文版);2010-02
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