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《Chinese Journal of Pharmacovigilance》 2010-05
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Comparative Study on Acute Toxicity of Different Components of Radix et Rhizome Sophorae Tonkinensis in Mice

SUN Rong1* YANG Qian2 ZHAO Yan3(1Shandong Academy of Chinese Medicine,Shandong Jinan 250014,China;2Shandong University of Traditional Chinese Medicine,Shandong Jinan 250355,China;3Center for Drug Reevaluation,SFDA,Beijing 100045,China)  
Objective Compare the acute toxicity of different components of Radix et Rhizome Sophorae Tonkinensis and to provide experimental data for safe use in clinal.Methods Different components of Radix et Rhizome Sophorae Tonkinensis were administrated to KM mice.The MTD of all-components and the LD50 of water extract,alcohol extract and total alkaloid extract of Radix et Rhizome Sophorae Tonkinensis were tested by the classical methods of acute toxicity.The acute toxic symptoms were observed;the accumulated death number and the weight-changes of live mice were recorded.Results The MTD of all-components of Radix et Rhizome Sophorae Tonkinensis was 10.68g·kg-1.The LD50 of water extract,alcohol extract and total alkaloid extract of Radix et Rhizome Sophorae Tonkinensis were 17.469(15.450~19.701)g·kg-1,27.135(24.869~29.622)g·kg-1,13.399(12.016~14.899)g·kg-1 in mice.Restlessness,breathlessness and convulsion were the main acute tixical symptoms.Conclusion The size order of acute toxicity of different components in Radix et Rhizome Sophorae Tonkinensis is total alkaloid extractwater extract all-componentsalcohol extract.The toxical components and toxical mechanism should be researched furtherly.
【Fund】: 国家重点基础研究发展计划(973)中医基础理论专项资助项目(2009CB522802);; 山东省科技平台建设项目课题 (课题编号:2008GG2NS02021)
【CateGory Index】: R285.5
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【References】
Chinese Journal Full-text Database 1 Hits
1 YANG Qian1 ZHENG Li-na2 XIE Yuan-zhang1 SUN Rong3*(1Shandong University of Traditional Chinese Medicine,Shandong Jinan 250355,China;2Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;3Shandong Academy of Chinese Medicine,Shandong Jinan 250014,China);Study on The"Dosage-Time-Toxicity"Relationship of Hepatotoxicity Induced by Different Components of Radix et Rhizoma Sophorae Tonkinensis in Mice[J];Chinese Journal of Pharmacovigilance;2010-07
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Department of Pharmacology Liao Jie, Zhang Bao-heng;ANTI-INFLAMMATORY EFFECTS OF OXYMATRINE[J];;1988-04
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Department of Pharmacology Liao Jie, Zhang Bao-heng;ANTI-INFLAMMATORY EFFECTS OF OXYMATRINE[J];;1988-04
2 Zhao Boguang (Yanchi Pharmaceutical Factory, Ningxia);STUDIES ON THE ALKALOIDS OF SOPHORA ALOPECUROIDES L.[J];Acta Pharmaceutica Sinica;1980-03
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