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《Chinese Journal of Pharmacovigilance》 2010-06
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Analysis of 5 Reports of Acute Liver Damage Induced by Zhixue Capsule

YANG Wan-hua HE Juan (Department of Pharmacy,Ruijin Hospital Affiliated to Shanghai JiaoTong University School of Medicine,Shanghai 200025,China)  
Objective The epidemiological characteristics of acute liver damage induced by Zhixue Capsule was investigated. Methods The severe adverse drug reactions(ADR) reports on liver damage induced by Zhixue Capsule have been analyzed retrospectively. Results 5 patients administered the Zhixue Capsule and the average medication time was(22+ 12) days. The clinical manifestations of the acute liver damage induced by Zhixue Capsule included jaundice,fatigue,fever,abdominal distension,nausea,anorexia and poor appetite. Liver function examination showed that the alanine aminotransferase(ALT) was between 599~3380 U/L,the total bilirubin(TBIL) was between 5.6~489μmol/L,and the eosinophilic granulocyte also get higher after administration. Conclusion The densefruit pittany root-bark in Zhixue Capasule may be the major cawse of the acute liver damage. So it suggest that clinician should determine the treatment based on differentiation of sym ptoms and signs to Drug-induced liver damage should be evaluated,and promote rational use of drugs,decrease the incidence of adverse drug reactions.
【CateGory Index】: R595.3
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