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《Chinese Journal of Pharmacovigilance》 2011-04
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Experimental Study on Mice's Acute Toxicity of Yangxue Shengfa Capsules

XIE Yuan-zhang1,2 SUN Rong1 ZHANG Ya-nan3 QIAN Xiao-lu3(1Shandong Research Academy of TCM,Shandong Jinan 250014,China;2Harbin University of Commerce,Heilongjiang Harbin 150000,China;3Shandong University of TCM,Shandong Jinan 250355,China)  
Objective To discuss the effect of Yangxue Shengfa capsules on mice's acute toxicity.Methods The classical method of acute toxicity were used to study on mice's caused by Yangxue Shengfa capsules.Results Caculated by Yangxue Shengfa capsules,the MLD is 24.0g·kg-1·d-1,which is equal to 420.0 times of 70kg people's daily dried medicinal herb expenses.The main acute toxicity symptoms of mouse are negligent action,diarrhea and hypokinesia.Compared with the control group,The mice's body-weight gainings were slow after 1 day's administration,which gradually normal after 5 day's administration and there were no other obvious abnormalities.The serum concentration of ALT and AST,the liver-body ratio all increased after 2 hours' administration.Conclusion The mice's acute toxicity of Yangxue Shengfa capsules could induce the liver injury although could not make the LD50 and MTD,and the mice did not appear dead.It demonstrated that the drug gavages certain dose to mice could cause obvious hepa-injury,which in accordance with the clinical ADR report.
【Fund】: 国家重点基础研究发展计划(973)中医基础理论专项资助项目(2009CB522802);; 山东省科技平台建设项目课题(2008GG2NS02021)
【CateGory Index】: R285.5
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