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《Chinese Journal of Pharmacovigilance》 2011-04
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Experimental Study on Mice's Acute Toxicity of Yangxue Shengfa Capsules

XIE Yuan-zhang1,2 SUN Rong1 ZHANG Ya-nan3 QIAN Xiao-lu3(1Shandong Research Academy of TCM,Shandong Jinan 250014,China;2Harbin University of Commerce,Heilongjiang Harbin 150000,China;3Shandong University of TCM,Shandong Jinan 250355,China)  
Objective To discuss the effect of Yangxue Shengfa capsules on mice's acute toxicity.Methods The classical method of acute toxicity were used to study on mice's caused by Yangxue Shengfa capsules.Results Caculated by Yangxue Shengfa capsules,the MLD is 24.0g·kg-1·d-1,which is equal to 420.0 times of 70kg people's daily dried medicinal herb expenses.The main acute toxicity symptoms of mouse are negligent action,diarrhea and hypokinesia.Compared with the control group,The mice's body-weight gainings were slow after 1 day's administration,which gradually normal after 5 day's administration and there were no other obvious abnormalities.The serum concentration of ALT and AST,the liver-body ratio all increased after 2 hours' administration.Conclusion The mice's acute toxicity of Yangxue Shengfa capsules could induce the liver injury although could not make the LD50 and MTD,and the mice did not appear dead.It demonstrated that the drug gavages certain dose to mice could cause obvious hepa-injury,which in accordance with the clinical ADR report.
【Fund】: 国家重点基础研究发展计划(973)中医基础理论专项资助项目(2009CB522802);; 山东省科技平台建设项目课题(2008GG2NS02021)
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 5 Hits
1 CHEN Fu-rong,YUE Nan,ZHI De-guang,ZHAO Yi-gui(Center for Drug Evaluation and Research,Tianjin Institute of Pharmaceutical Reseach,Tianjin 300193,China);The effect and mechanism of Yangxue Shengfa Capsules on hair growth in mice[J];Drugs & Clinic;2010-02
2 ;Hepatitis due to the concomitant administration of Shouwu tablets and Yangxue Shengfa capsules[J];Adverse Drug Reactions Journal;2004-05
3 WANG Pei-pei1,ZHANG Yu1,WANG Kai-ping2(1. Pharmaceutical Preparation Section of Union Hospital,Tongji Medical College of Huazhong University of Science and Technology,Hubei Wuhan 430022,China; 2. Faculty of Pharmacy,Tongji Medical College of Huazhong University of Science and Technology,Hubei Wuhan 430030,China);Acute toxicology of Angelica Sinensis polysaccharide-iron complex by oral administration in mice[J];Chinese Journal of Hospital Pharmacy;2009-04
4 DU Jun- rong~(1), BAI Bo~(2), YU Yan~(2), WANG Cheng-yuan~(1), QIAN Zhong-ming~(1,3)(1. Department of Applied Biology and Chemistry, The Hong Kong Polytechnic University, Hong Kong, China;2. Department of Pharmacology, West China School of Pharmacy Sichuan University, Chengdu 610041, China;3. Department of Pharmacology, Capital University of Medical Sciences, Beijing 100054, China);The new progress of the study about volatile oil of the angelica[J];China Journal of Chinese Materia Medica;2005-18
5 Wu Yanli, Cui Qizhen, Du Qun, Wang Rujun (Piwei Institute, Guangzhou University of TCM, Guangzhou 510405);Effect of Yangxue Shengfa Capsule (养血生发胶囊) on hair growth[J];Pharmacology and Clinics of Chinese Materia Medica;2004-04
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 YANG Shi You, HUANG Shi Fu,SUN Bei,TIAN Jun (Anhui Institute of Pharmacy,Hefei 230022 );Effect of beishao jieyu granules in depression model mice[J];Anhui Medical and Pharmaceutical Journal;2004-02
2 WANG Shi-hong~(1,2),WEI Wei~(1),XU Du-juan~(1),XU Shu-ping~(1),CUI Ying~(2)(1.Institute of Clinical Pharmacology,Anhui Medical University;Anhui Key Laboratory of Antiinflammatory and Immunopharmacology;Anhui Provincial Key Laboratory of R&D of Chinese Medicine,Hefei 230032;2.He'nan College of TCM,Zhengzhou 450008);Proliferation inhibition of TGP on SMMC-7721 Cell in vitro[J];Anhui Medical and Pharmaceutical Journal;2006-01
3 WANG Xiao-ming~1,LI Fu-biao~2,LU Wen-wei~3,CHEN Xia~(3)(1.Department of Cardiology,First Hospital,Jilin University,Changchun 130021,China;2.Department of Urology,First Hospital,Jilin University,Changchun 130021,China;3.Department of Pharmacology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China);Protective effects of total glycosides of Pacony on acute myocardial ischemia in dogs[J];Journal of Jilin University(Medicine Edition);2006-03
4 CHEN Nan~1,XUE Dun-yuan~2(1.Department of Chemistry, Lanzhou University, Lanzhou Gansu 730000;2.Instrumental Analysis & Research Center, Lanzhou University, Lanzhou Gansu 730000, China);Studies on the SC-CO_2 Extracted Essential oil of Angelica Sinsis ——Analysis of the Ingredents of the Sce Extracted Essential oil By Capillary Column GC/MS[J];Journal of Gansu Education College(Natural Science Edition);2003-04
5 FAN Wei- xin, ZHU Wen- yuan(Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029);Study on the mechanism of cyclosporin A in stimulating hair growth[J];Journal of Clinical Dermatology;2000-05
6 Yang Qingli (Dept.of Pharmacology,Lanzhou Medical College);A Study of Some Pharmacological Effects of Angelica Volatile Oil[J];Journal of Lanzhou University Medical Sciences;1986-03
7 DONG Yan 1,WEI Xing-guo 1,CUI Qing-xin 2,ZHANG Gui-ling 1 (1.Dezhou University,Dezhou 253023,China;2.Liaocheng University,Liaocheng 252029,China);Analysis on chemical constituents of essential oil from angelica sinensis[J];Shandong Journal of Traditional Chinese Medicine;2004-01
8 HAN Xiang hui, LI Jing cai (Department of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China);Advances in the pathology and pharmacology of alopecia[J];Journal of Shenyang Pharmaceutical University;2001-03
9 HUANG Bao- hua1, ZHANG Kun1, GUAN Yan- qiong1, ZHOU Xiao- hui2(1 Light Industry and Chemical Engineering School, Guangdong University of Technology, Guangzhou 510090, China;2 Experiment Research Center, Guangdong University of Technology, Guangzhou;Determination of Ligustilide in Radix Angelicae Sinensis by SFE-Capillary GC[J];Journal of Instrumental Analysis;2002-04
10 Lin Xianming, Hu Benrong, Li Zhen et al Department of Pharmacology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030;Regulation of Connexin43 Expression by p42/44MAPK in PGF_(2α)-induced Rat Myometrium Contraction[J];Acta Universitatis Medictnae Tangji;2002-04
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