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《Chinese Remedies & Clinics》 2005-08
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Relationship of the changes of diabetic's serum C-reactive protein,tumor necrosis factor-α with their periodontal disease

LIU Jie*,HU Ling,QIN-Jie,KANG Wen-juan,YANG Yan-lan,HAO Mei,YUAN Shao-zhong.*Endocrinology Department of Shanxi Provncial People's Hospital,Taiyuan 030012,China  
Objective To study on the relationship between the changes of serum C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) in patients with type 2 diabetes mellitus (T2DM) and their periodontal disease. Methods T2DM (n=584) as examined group, the level of serum CRP, TNF-α and periodontal status were determined, non-diabetic people as control group. Results The prevalence of periodontal disease was 63.7% in T2DM,and 21.6% in control group. The serum level of CRP and TNF-α in T2DM group was higher than that in control group (P0.01). Serum level of CRP in periodontal disease was higher than that in non- periodontal disease with T2DM(P0.001). Conclusion The prevalence of periodontal disease is high in patients with T2DM.Detection of serum CRP and TNF-α might know the complication progress in diabetes.Treating T2DM must pay attention to prevention and cure of periodontal disease simultantously.
【Fund】: 山西省科技厅科技攻关基金资助项目(002050)
【CateGory Index】: R587.1
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