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《Chinese Remedies & Clinics》 2007-11
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Study on the proliferative inhibition and apoptosis of human gastric cancer cells with treatment of caesalpinia sappan L. extract

WANG Xue*, ZHAO Su-lian, XU Jian-guo, ZHAO Ying-fang. *Department of Immunology, Shanxi Medical University, Taiyuan 030001, China  
Objective To illustrate the growth inhibition and apoptosis in human gastric cancer (SGC-7901) cells treated with extracts of caesalpinia sappan L. Methods The growth curve was mapped according to cell counts to reflect the proliferation of cancer cells. Morphological changes of cells were observed by means of HE staining and fluorescence staining. DNA ladder was examined by DNA agarose gel electrophoresis. Results The growth curve of the cell line showed inhibitory effects of Caesalpinia sappan L. extracts on cell proliferation. Changes in morphology typical of apoptosis were observed 48 h following treatment with caesalpinia sappan L. extracts, which appeared somewhat dose-dependent. Typical DNA ladders were identified with agarose gel electrophoresis. Conclusion Caesalpinia sappan L. extracts may obviously inhibit SGC-7901 cell proliferation and induce cell apoptosis.
【CateGory Index】: R735.2
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