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《Drug Evaluation Research》 2014-02
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Research progress in Coicis Semen against metabolism syndrome

ZHANG Ming-fa;SHEN Ya-qin;Shanghai Meiyou Pharmaceutical Co., Ltd.;  
Coicis Semen extract and its active constituents show hypoglycemic and hypolipidemic effects on various models of diabetic and hyperlipidemic obesity animals, and also effective in antagonism to metabolism syndrome induced by hyperglycemia and hyperlipidemia and its complications(oxidative stress, artherosclerosis, cerebral ischemia, and abnormal immune function). Its active constituents include coixans, hydroxyl unsaturated fatty acid, and polyphenols. Its active mechanisms are relative to the enhancement of glucose utilization and glucokinase activity in tissue, improve the disorder of glycometabolism and insulin resistance, and to antagonize oxidative stress-induced cell injury by activation of Nrf2/ARE-depentent cytoprotective genes, and so on. Research progress in Coicis Semen and its active constituents with the function against metabolism syndrome is reviewed.
【Fund】: 国家自然科学基金资助项目(39370838)
【CateGory Index】: R285
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