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《Pharmaceutical Biotechnology》 2007-02
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Study on Purification of Vancomycin Fermentation Broth with Macroporous Adsorbent Resin

ZHANG Yi1,DU Lian-xiang1,MA Shu-zhang1,ZHANG Ying2(1.Tianjin Key Lab of Industrial Microbiology,School of Biotechnology,Tianjin University of Science and Technology,Tianjin 300457 China;2. Tianjin Soil Fertilizer Workstation,Tianjin 300061,China)  
To study the process condition of the purification of vancomycin fermentation broth,the characteristics of static adsorption and desorption of six kinds of macroporous adsorbent resin to vancomycin were studied.The most suitable resin was selected to carry out the dynamic adsorption experiment.The concentration,pH value,flow rate of the infusion on the adsorption of the resin and the elution process were also studied.The XAD-16 resin was selected to carry out the dynamic adsorption experiment.The suitable concentration,pH value,and the flow rate of the infusion were 2.09mg/ml,9.0 and 2.5ml/min respectively.Using 10% ethanol/0.1% hydrochloric acid/water as elution solvent,vancomycin adsorbed on the resin was substantially eluted at a flow rate of 1.5ml/min,and after the adsorption and desorption of XAD-16 resin to vancomycin fermentation broth,the HPLC peak area percentage of vancomycin in the eluant could reach 85.61%.
【CateGory Index】: R944
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