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《Journal of Medical Pest Control》 2014-09
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Influences on different doses of avermectin active compound on the humoral immune function in mice

WANG Jian min;Hebei medical university the 4th hospital;  
Objective To study the different dosages avermectin technical effect of the humoral immune function in Kunming mice. Methods 30 Kunming mice were randomly divided into A,B,C,D 4 groups,each group of 10. In accordance with the group A 20 mg /kg avermectin dose in Kunming mice infected; Group B according to the 10 mg /kg avermectin dose in Kunming mice infected; group C according to the 5 mg /kg avermectin dose in Kunming mice infected; group D was given vegetable oil instead of avermectin in Kunming mice as the negative control group. Through the mouth for 28 days,compare the four groups half hemolysis( HC50) value determination,antibody generation cell detection( PFC),white blood cells( WBC),total protein( TP),albumin( alb),immunoglobulin G( IgG),the level of immunoglobulin M( IgM). Results Group A HC50,PFC,WBC,TP,propagated,IgG,IgM levels are lower than that of group D,differences had statistical significance( P 0. 05),and group B is lower than that of group D,TP,IgG diff had statistical significance( P 0. 05). Conclusions To Kunming mice 20 mg/kg dose of avermectin technical can be immune to its inhibition effect.
【CateGory Index】: R965
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2 WANG Jian min;Hebei medical university the 4th hospital;;Influences on different doses of avermectin active compound on the humoral immune function in mice[J];医学动物防制;2014-09
3 YANG Jun-hong;HE Ji-hong;HOU Xiao-lin;QI Peng;WU Jia-xin;China Animal Husbandry Group;China Animal Husbandry Industry CO. LTD;Beijing University of Agriculture;;An ELISA method to detect the residue of avermectins in bovine tissues[J];中国兽医杂志;2014-09
4 HAN Fei;ZHANG Man;ZHANG Zhou;WANG Jing-yu;Vocational and Technical College of Yangling;College of Veterinary Medicine,Northwest A&F University;;Pharmacokinetics and Residue Detection of Avermectin in vivo Fishes:A Review[J];动物医学进展;2014-08
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