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《The Journal of Medical Theory and Practice》 2006-05
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The Effect Mechanism of Gynostemma Pentaphyllum Makino to Hippocampus in Aged Rats Induced by D-galactose

LIU Guohui*,YAO Dandan,LU Jiayi,et al.Guangzhou Medical College,Guangzhou City,Guangdong Province 510182  
Objective: To study the effect machanism of Gynostemma pentaphyllum Makino to hippocampus in aged rats induced by D-galactose.Methods: 40 SD rats were randomly and egually divided into four groups:group 1: Normal,group 2: model,group3:given gastriclavage with Salines,and group4:with Gynostemma pentaphyllum Makino(100mg/kg).After 40 days,the activities of SOD,MDA,NO,NOS were measured with colorimetric method in hippocampus,and the changes of weight and the index of thymus and spleen were observed.Results: In group 2 the content of SOD was lower and the activities of MDA,NO and NOS were higher than group 1(P0.01).In group 4 the SOD activity was significantly increased,the activities of MDA,NO,NOS were decreased,the weight of rats had no change significantly(P0.01),and the index of thymus and spleen increased significantly than that in group 1(P0.01).Conclusion: Gynostemma pentaphyllum has strong free radical that has scavenging activity in hippocampus,and may increase the weight of immunity organs and restrain the activities NO.
【CateGory Index】: R285
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