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《The Journal of Medical Theory and Practice》 2007-10
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Effects of Gynostemma Pentaphyllum Makino on Hypothalamus in Aging Rats and Its Mechanisms

YAO Dandan*,HUANG Shanhua,LIU Guohui.Physiology Department of Conghua School,Guangzhou Medical Collge,Guangdong Province 510925  
Objective:To study the effects of Gynostemma pentaphyllum Makino on hypothalamus in sub-acutely aging rats and its mechanisms.Methods:40 SD rats were randomly divideded into four groups:normal group,model group,salines group and Gynostemma pentaphyllum Makino group.Rats were injected D-galactose to make the sub-acutely aging model.The activities of SOD、MDA、GSH-Px、NO、NOS and the content of Glu in hippocampus were measured by spectrophotometer.Results:In the sub-acutely aging model group,the content of SOD、GSH-Px were lower and the activities of MDA、NO、NOS and Glu were higher than normal group(P0.01).In Gynostemma pentaphyllum Makino group,the activity of SOD、 GSH-Px significantly increased,the content of MDA、NO、NOS decreased,and the Glu activity in the hippocampus was inhibited in aging mice compared with the normal group.Conclusion:Gynostemma pentaphyllum can restrain the activities of Glu and NO,and there is strong scavenging capacities on free radicals in aging rats's hippocampus.
【CateGory Index】: R285.5
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