Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《The Journal of Medical Theory and Practice》 2007-10
Add to Favorite Get Latest Update

Effects of Gynostemma Pentaphyllum Makino on Hypothalamus in Aging Rats and Its Mechanisms

YAO Dandan*,HUANG Shanhua,LIU Guohui.Physiology Department of Conghua School,Guangzhou Medical Collge,Guangdong Province 510925  
Objective:To study the effects of Gynostemma pentaphyllum Makino on hypothalamus in sub-acutely aging rats and its mechanisms.Methods:40 SD rats were randomly divideded into four groups:normal group,model group,salines group and Gynostemma pentaphyllum Makino group.Rats were injected D-galactose to make the sub-acutely aging model.The activities of SOD、MDA、GSH-Px、NO、NOS and the content of Glu in hippocampus were measured by spectrophotometer.Results:In the sub-acutely aging model group,the content of SOD、GSH-Px were lower and the activities of MDA、NO、NOS and Glu were higher than normal group(P0.01).In Gynostemma pentaphyllum Makino group,the activity of SOD、 GSH-Px significantly increased,the content of MDA、NO、NOS decreased,and the Glu activity in the hippocampus was inhibited in aging mice compared with the normal group.Conclusion:Gynostemma pentaphyllum can restrain the activities of Glu and NO,and there is strong scavenging capacities on free radicals in aging rats's hippocampus.
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 1 Hits
1 Yun-Hua Cui, Xiao-Ling Wang, Qing Liu, Section of Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, ChinaPing Liu, Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine;Influences of anti-oxidation of salvianolic acid B on proliferation of rat cultured hepatic stellate cells[J];World Chinese Journal of Digestology;2002-03
Chinese Journal Full-text Database 10 Hits
1 Ye Ping1,2,Yang Bo1,Tang Wen1,Zhuo Qiang3,Zheng Renyuan3,Jiang Mingde1(1Department of Gastroenterology,General Hospital of Chengdu Military Command,ChengDu,Sichuan Province,610083;3 Department of Outpatients,Chengdu Medical College,Chengdu,Sichuan Province,610083,China);p38MAPK signal pathway modulates proliferation,apoptosis and cell cycle of rat hepatic stellate cells stimulated by acetaldehyde[J];Acta Academiae Medicinae Militaris Tertiae;2010-20
2 JIANG Ming-De 1, MA Hong-De 2, ZHONG Xian-Fei 1, ZENG Wei-Zheng 1 1Department of Digestive Diseases, General Hospital of Chengdu Military Command, Chengdu 610083, China, 2The First People Hospital, Pingdingshan City 467000, China;Effect of salidroside on rat hepatic stellate cells stimulated by acetaldehyde[J];Journal of The Fourth Military Medical University;2005-14
3 PIAO Long 1, ZHANG Xue-Wu 2, JIN Xiang-Zi 1, LI Shan-Hua 2(1.Department of Histology and Embryology, College of Medicine, Yanbian Universi ty, Yanji, Jilin Province 133000, China;2. Department of Biochmistry, College o f Medicine, Yanbian University, Yanji, Jilin Province 133000, China);Effect of WTHXBoschniakia rossica extract on fr ee radicals in brain of D-galactose induced senile rats[J];Journal of Chinese Integrative Medicine;2003-02
4 YAO Dan-dan,HUANG Shan-hua(Conghua College of Guangzhou Medical College,Conghua 510925,Guangdong,China);Study on the anti-aging function of Gynostemma pentaphyllum Makino on sub-aging rats[J];Modern Journal of Integrated Traditional Chinese and Western Medicine;2007-28
5 LI Xin-rong HU Jian-fang(Department of Digestive System Diseases,Nanchang 330006,China);Research Progress in Anti-Hepatic Fibrosis Effects of Salvia Miltiorrhiza[J];Modern Diagnosis & Treatment;2008-01
6 Jiang MingDe, MA Hong - de, ZHONG Xian - fei, ZENG Wei - zheng, Department of Gastroenteiology, General Hospital of Chengdu Military Command, Chengdu 610083.;Effect Of Chinese medidne salidroside on the cell cyde ofhepatic stellate cells in rats stimulated by acetaldehyde[J];Medicial Journal of National Defending Forces in Southwest China;2003-04
7 LIU Guohui*,YAO Dandan,LU Jiayi,et al.Guangzhou Medical College,Guangzhou City,Guangdong Province 510182;The Effect Mechanism of Gynostemma Pentaphyllum Makino to Hippocampus in Aged Rats Induced by D-galactose[J];The Journal of Medical Theory and Practice;2006-05
8 LI Ya-Li,CHU Wei,GUO Wen-Chao,et al.Hebei Medical University,Shijiazhuang 050000,Hebei,China;The effect of Heshouwu decoction on anti-oxidation and blood lipid of aging rats[J];Chinese Journal of Gerontology;2008-06
9 Siriguleng,Aoen Bolige,WANG Jin-Niu.Keshiketengqi Hospital,Chifeng 025350,Inner Mongolia,China;Effects of Mongolian medicine Sujid-11 on testis functions of ageing accelerating model mice[J];Chinese Journal of Gerontology;2011-09
10 LI Ya-li1,2,ZHANG Na3,XING En-hong4,GAO Fu-lu1,CHU Wei2,WANG Fang-na2(1 Hebei Medical University,Shijiazhuang 050017,China;2 Center of Birth Health,Excellent Growth and Education,The People's Hospital of Hebei Province,Shijiazhuang 050051,China;3 The Forth Hospital of Hebei Medical University,Shijiazhuang 050011,China;4 The Hospital of Chengde Medical College,Chengde 067000,China);Anti-oxidative and blood lipid-lowering effects of Heshouwuyin in sub-acutely aging rats[J];Chinese Journal of New Drugs;2008-04
Chinese Journal Full-text Database 10 Hits
1 LI Xia,YUAN Feng-lai,YUAN Li-ping,CHEN Fei-hu (School of Pharmacology,Anhui Medical University,Hefei 230032,China);Progressive research on the effect of polyunsaturated fatty acids in regulation of plasma lipids[J];Anhui Medical and Pharmaceutical Journal;2007-10
2 YANG Qi-gang~(1,2),CHEN Gui-hai~1(1.Department of Neurology,the Affiliated Hospital of Anhui Medical University,Hefei 230032;2.Department of Neurology,Anhui Hospital of Chinese People′s Armed Police Forces,Heifei 230041);Effects of age on ability of novel-object recognition in senescence-accelerated prone mouse 8[J];Journal of Anhui Agricultural University;2006-02
3 TAN Hua-bing(Medical Department,The People's Hospital of Yunyang Medical College,Shiyan 442000,China);Effect of Fiveleaf Gynostemma Herb on hyperlipoidemia and hemorheological changes in rabbits[J];Acta Academiae Medicinae Militaris Tertiae;2007-15
4 Zhang Ling,Lan Shaoyang,Li Lingjun,et al.The 8th People's Hospital,Guangzhou 510060,China;Research of the relationship of glucose metabolism disorder and liver fibrosis in patients with cirrhosis[J];Journal of Clinical Hepatology;2006-01
5 DONG Lei1,JIANG Ning1,ZHOU Wen-Xia1*,ZHANG Yong-Xiang1,GENG Miao1,ZHANG Xue-Min2,LIU Bing-Yu2,WANG Jie2(1.Beijing Institute of Pharmacology and Toxicology,2.National Center of Biomedical Analysis,Beijing 100850,China);Preliminary Study on Hippocampal Proteomics of Senescence-accelerated Mouse[J];Chemical Journal of Chinese Universities;2007-02
6 YU Xin 1, LI Yuan-zhi 2,CHEN Yue 1 (1 Food Sci.Dept.,Zhongkai Agrotechnical College,Guangzhou 510225) (2 Food Sci.Dept., South China Agric.Univ.,Guangzhou 510642);Study on the Extraction of Gynostemma pentephyllum and its Stability in the Solution[J];Guangzhou Food Science and Technology;2002-01
7 Wei Zhixian,Ran Min,Li Baozhang,Fan Hengxin (Department of Chemical Engineering,Northwest University,Xi'an 710069);Study on Adsorption of Gypenosides over D 101 Resin[J];CHEMICAL ENGINEERING(CHINA);1998-05
8 TAN Zhen hua,FENG Qi guo,directed by:WANG Yao bin (Liaoning College of TCM,Liaoning Shenyang 110032,China);Survey of Aucupuncture and Moxibustion Treatment of Hyperlipemia and Atherosclerosis[J];LIAONING JOURNAL OF TRADITIONAL CHINESE MEDICINE;2000-01
9 ZHOU Xiao-ping,MA Yan-hong,FU Yan-ling(Beijing University of Traditional Chinese Medicine,Beijing 100029,China);Strengthening Spleen and Supplementing Lung:the anti-aging effects on skin of mice modle established by D-galactose[J];Chinese Journal of Aesthetic Medicine;2007-02
10 Fu Huabin,Wang Lin,Yang Qingwu,et al.Department of Neurology,Daping Hospital,Third Military Medical University,Chongqing 400042,China;Relationship between glucose cholesterol and cognitive impairment in patients with acute stroke.[J];Sichuan Medical Journal;2007-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved