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《Chinese Journal of the Frontiers of Medical Science(Electronic Version)》 2016-02
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Analysis of the eradication G17 and PG content changes and clinical significance of Hp eradication in patients with Hp related chronic stomach disease

ZHU Qi;XIONG Hua;ZHANG Rao;LU Hong;Aini·Abudureyimu;Department of Gastroenterology,Shanghai Jiao Tong University School of Medicine;Department of Gastroenterology, Kashgar Prefecture Second People's Hospital;  
Objective To analyz the eradication G17 and PG content changes and clinical significance of Hp eradication in patients with Hp related chronic stomach disease. Method 200 cases of healthy physical examination as control group, with 200 Hp correlation gastropathy patients as observation group, compared the levels of G17, PG Ⅰ, PG Ⅱ and PG Ⅰ /PG Ⅱ between the two groups. And compared the levels of G17, PG Ⅰ, PG Ⅱ and PG Ⅰ /PG Ⅱ and indigestion symptoms of different treatment effect and different types of two groups before and after treatment. Result The levels of G17, PG Ⅰ and PG Ⅱ of observation group were significantly higher than control group(P 0.05), and PG Ⅰ /PG Ⅱ tatio was significantly lower than control group(P 0.05). There were no obvious differences of G17, PG Ⅰ, PG Ⅱ and PG Ⅰ /PG Ⅱbefore and after treatment in observation group of Hp not eradicator(P 0.05). After treatment, the levels of G17, PG Ⅰ and PG Ⅱ of Hp eradicator were significantly lower than before treatment and Hp not eradicator(P 0.05), PG Ⅰ /PG Ⅱ ratio was significantly higher than Hp not eradicator(P 0.05). There was no obvious difference of DSSI scores before treatment in Hp eradicator or not eradicator(P 0.05), but in 1 month treatment, the DSSI score of Hp eradicator was significantly lower than Hp not eradicator(P 0.05). There were obvious differences of G17, PG Ⅰ, PG Ⅱ and PG Ⅰ /PG Ⅱ among the three groups before and after treatment(P 0.05), all at the highest of gastric polyps patients, with lowest of atrophic gastritis patients(P 0.05). Conclusion The levels of serum G17 and PG are significantly increased in patients with Hp related gastric disease, The levels of serum G17 and PG are significantly improved after Hp eradication, they can be used as an effective index to evaluate the effect of Hp eradication.
【Fund】: 新疆少数民族科技人才特殊培养计划科研项目(NO.201523104)
【CateGory Index】: R573
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