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《THE JOURNAL OF PHARMACEUTICAL PRACTICE》 1999-05
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Effects of gypenosides on neoplasm growth and immunity function of Lewis lung neoplasm grafted mice

Liang Jun,Tang Xiaofang, Wei Xiaolong(The Outpatient Department,Material and Supplying Station of Beijing Military District,Beijing 100071)  
OBJECTIVE:To study the effects of Gypenosides (GPs) on neoplasm growth, total number of splenic cells and NK cell activity. METHODS:Antitumor experiment in mice was made and the total number of splenic cells and NK cell activity were determined. RESULTS:GPs could significantly inhibit the growth of Lewis lung cancer in mice. The inhibiting rates of tumor were (30.7±1 2)%,(51 5±2 5)% and (50.3±1.5)% ( P 0 01) after ip GPs 10,20 and 40mg/kg,respectively. The total number of splenic cells and the NK cell activity of both PBL and splenic cells were elevated. CONCLUSION:The antitumor effect of GPs is related to the elevated immunological function of tumor grafted mice.
【CateGory Index】: R734.2
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