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Preparation of Puerarin by microemulsion drug delivery system

Chen Han1,Zhong Yan-qiang2,Lu Ying2(1.China;2.College of Pharmacy,Second Military Medical University,Shanghai 200433,China)  
Objective: To develop a microemulsion drug delivery system of Puerarin(PUE-ME).Methods:Formulation of PUE-ME was screened by solubility experiments,compatibility tests and pseudo-ternary phase diagrams,with the consequence of visual examination as parameter.Results: The maximum drug corporation was 77.11 mg/mL.The formulation was composed of IPM(10%),brij-96V(37.5%),ethanol(37.5%),and water(25%).Conclusion:The formulation of PUE-ME preparation could meet the general requirements of the design.
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