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Preparation and in vitro evaluation of ketoprofen gel for transdermal drug delivery

Hu Jinhong,Zhang Wanguo,Zheng Xiaomei (Department of Pharmacy,Changhai Hospital,Shanghai200433)  
OBJECTIVE: To study the prepartion of ketoprofen gel and its in vitro release. METHODS: PVA and glycerin was used as carriers.RESULTS: KFP was delivered at zero order.The higher the drug content,the faster the delivery speed.5% urea had no effect on KFP transdermal delivery.At a content of more than 10%,urea could significantly accelerate KFP transdermal delivery. CONCLUSION: Gel was stable and accorded the clinical demands.
【CateGory Index】: R944.9
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