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《Medical Information(Section of Operative Surgery)》 2007-03
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Effect of Lobeline on 6-OHDA-induced Rat Model of Parkinson’s Disease

LI Chao-yue,SHI Xi-wen,ZHANG Jian-guo,et al(Department of Neurosurgery,Henan Provincial People's Hospital,Zhengzhou 450003,Henan Province,China)  
Objective Study on effect of lobeline on 6-OHDA-treated rat Model of Parkinson’s Disease.Methods Rat treated were examined by behavioral tests(emetomorphine-induced rotation) and tyrosine hydroxylase (TH) immunohistochemistry was stained to dopaminergic neurons in substantia nigra.Results The results demonstrated lobeline could increased significantly TH positive neurons in substantia nigra and reversed locomotor deficits detected in MPTP-treated mice(P0.05).Conclusions Lobeline may be useful to treat symptoms in Parkinson’s disease and protect dopaminergic neurons against neurotoxin in vivo.
【Key Words】: lobeline Parkinson’s Disease 6-OHDA
【CateGory Index】: R285
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