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《Acta Pharmaceutica Sinica》 1982-03
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STUDIES ON THE EFFICACY OF ARTEMETHER IN EXPERIMENTAL SCHISTOSOMIASIS

LE Wen-ju, YOU Ji-qing, YANG Yuan-qing, MEI Jing-yan, GUO Hui-fang, YANG Hui-zhong and ZHANG Chao-wei(Institute of Parasitic Diseases, Chinese Academy of Medical Sciences, Shanghai)  
Artemether (Dihydro-artemisinine-12-β-methyl ether), an ether derivative of reduced qinghaosu, has been found to possess schistosomicidal actions.Mice, rabbits and dogs were exposed to 50±2 and 250±2 of Schistosoma japonicum cercariae. When infected mice were treated orally with artemether suspension at the dosages of 400~800 mg/kg in 1~4 day-course, the worm reduction rates were 55.3%~79.9%. If the drug in oil formulation was given subcutaneously, to infected mice at the dosages of 225~435 mg/kg in 3 day-course, the worm reduction rates were 70.5%~81.2%. In infected dogs treated orally with artemether suspension at the dosages of 25~35 mg/kg in 3 day-course, or treated intramuscularly with the drug in oil formulation at the dosages of 150~250 mg/kg in 5 day-course, the worm reduction rates were 52.6%~59.1% and 91.3%~99.3% respectively. Artemether was also effective against immature worms.When both infected and normal dogs were treated intramuscularly with artemether in oil formulation at the dosages of 30~90mg/kg/day for 5 days, anorexia and diarrhea occurred in some dogs, and subsided 4~5 days after the end of treatment. Three days after the end of medication, the average white blood cells were markedly decreased in uninfected dogs, but returned to normal 18 days after medication.Histo-patholgical changes of the normal dogs treated with artemether were examined. It was domonstrated that degeneration of mucosa of stomach and large intestine, villi of small intestine and epithelium of renal tubule; dilatation of blood vessels and retention of plasma in glomerulus; and fatty degeneration in liver and in adrenal were found. The above mentioned tissue alterations nearly recovered to normal 18~19 days or 30~31 days after the cessation of treatment. No significant changes were found in other tissues of the animals.
【Fund】: 联合国开发计划署/世界银行/世界卫生组织热带病研究培训特别规划~~
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【References】
Chinese Journal Full-text Database 10 Hits
1 BAO Guang-ming1,JIANG Xiao-hui1,TIAN Min-qing2,MA Ya-ping3,YUAN Hou-qun4,BAI Zhen-feng1 (1.Department of Chemistry and Chemical Engineering,China West Normal University,Nanchong 637002,China;2.Institute of Oceanology,Chinese Academy of Science,Qingdao 266071;3.Guangdong Engineering R&DCenter of Peptide Technology Shenzhen Hybio Engineering Co.,Ltd.Shenzhen 518057;4.Departinent of Material Science,Toyohashi University of Technology,Japan 441-8580);Capillary Gas Chromatographic Determination of Residual Organic Volatile Solvent in Artemether[J];Journal of China West Normal University(Natural Sciences);2007-02
2 ;Study on prevention and cure of artemeth er against schistosomiasis[J];Chinese Journal of Schistosomiasis Control;2005-04
3 Tu Zuwu1, Juerg Utzinger2, Jacques Chollet2, Xiao Shuhua3, Marcel Tanner2 (1 Hubei Provincial Center for Diseases Control and Prevention, Wuhan 430079, China; 2 Swiss Tropical Institute Switzerland; 3 Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, China);Therapeutic effect of artemether and artesunate in mice infected with Schistosoma mansoni[J];Chinese Journal of Schistosomiasis Control;2005-05
4 Li Zhao-hui1,Dong Xing-qi2 1 School of Public Health,Dali University,Dali 671000,China; 2 Yunnan Institute of Endemic Diseases Control and Prevention,China;Progress of research on antischistosomal drugs[J];Chinese Journal of Schistosomiasis Control;2009-04
5 Yue Wenju, You Jiqing, Mei JingyanInstitute of Parasitic Diseases, China National Centrefor Preventive Medicine, Shanghai;EFFECT OF ARTEMETHER ON TEGUMENTAL SURFACE ANTIGEN OF SCHISTOSOMA JAPONICUM[J];Chinese Journal of Parasitology and Parasitic Diseases;1984-03
6 Yue Wenju, Mei Jingyan, Xiao Shuhua Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine;EFFECTS OF PRAZIQUANTEL AND ARTEMETHER ON TEGUMENTAL SURFACE ANTIGENS OF DIFFERENT DEVELOPMENTAL STAGES OF SCHISTOSOMA JAPONICUM[J];Chinese Journal of Parasitology and Parasitic Diseases;1986-04
7 Xiao Shuhua; Shi Zhonggu; Zhuo Shangjiong; Wang Cunzhi;Zhang Zhigang; Chu Bo; Zheng Jiang; Chen Minggang(Institute of Parasitic Inseases, Chinese Academy of Prerentive Medicine, Shanghai 200025)(Office for Schistosomiasis Control Of Heshan District Yiyang;FIELD STUDIES ON PREVENTIVE EFFECT OF ARTEMETHER AGAINST INFECTION WITH SCHISTOSOMA JAPONICUM[J];Chinese Journal of Parasitology and Parasitic Diseases;1995-03
8 ZHAI Zili, MEI Jingyan, YOU Jiqing, YAO Minyi, XIAO Shuhua Institute of Parasitic Diseases,Chinese Academy of Preventive Medicine ** , Shanghai 200025;EFFECT OF ARTEMETHER ON NUCLEOSIDE UPTAKE AND NUCLEIC ACID CONTENT IN SCHISTOSOMA JAPONICUM *[J];CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES;1999-04
9 Xiao Shuhua, You Jiqing, Mei Jinyan, Jiao Peiying, Guo Huifang, Yang Yuanqing Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis. S;EXPERIMENTAL STUDIES ON THE PREVENTIVE EFFECT OF ARTEMETHER AGAINST SCHISTOSOMAL INFECTION[J];CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES;1995-04
10 LU Gang1,HU Xu-chu2,HUANG Can2,XIE Hong-yan2,XU Jing2,CHEN Shou-yi2,Wu Zhong-dao2,Yu Xin-bing2 (1 Department of Parasitology,Hainan Medical College,Haikou 571101,China;2 Department of Parasitology,School of Basic Medical Sciences,Sun Yat-Sen University,Guangzhou 510089,China);Effect of artmether,hemin and Fe~(3+) on recombinant lactate dehydrogenase from Schistosoma japonicum(rSj LDH)[J];Chinese Journal of Zoonoses;2008-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Ju xin*, WANG Shi xian, ZHANG Fu geng, ZHANG Yu hua Biotechnical Laboratory, Tianjin Medical & Pharmaceutical Institute, Tianjin 300070, P.R.China;Primary Study of Effect of Hypoxic Killing and Radiation Sensitivity of Artemisinin on Human Cervical Cancer Cell[J];Chinese Journal of Cancer;2001-12
2 Chen Hua, Gao Yuxiang (Department of Dermatology, Bengbu Medical College, Anhui);ARTESUNATE THERAPY IN ECZEMA-DERMATITIS AND PHOTOALLERGIC SKIN DISEASES ( PRELIMINARY OBSERVATION )[J];Journal of Bengbu Medical College;1991-04
3 Ho YI-HSUN AND YANG HUI-CHUNG(Shanghai Institute of Parasitic Diseases, Shanghai);HISTOLOGICAL AND HISTOCHEMICAL STUDIES ON THE EGG FORMATION OF SCHISTOSOMA JAPONICUM[J];Acta Zoologica Sinica;1974-03
4 Liu Jianfa(Teaching and Research Section of Parasitology, Shihezi Medical College, 832002)Chappell LH(Department of Zoology, Aberdeen University,AB9 2TN, UK);Effect of Cyclosporin A (CsA) Against Schistosoma mansoni in vitro[J];ENDEMIC DISEASES BULLETIN (CHINA);1997-01
5 ZHAI Zi li, YOU Ji qing, GUO Hui fang, JIAO Pei ying, MEI Jing yan, XIAO Shu hua (Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai 200025, China);Inhibition of Superoxide Dismutase and Glutathione Reductase of Schistosoma japonicum by Artemether[J];Endemic Diseases Bulletin (China);2002-04
6 Wei-Long Zou, Zhen Yang, Yun-Jin Zang, Dong-Jian Li, Zhi-Peng Liang and Zhong-Yang Shen Institute of Transplantation, General Hospital of the Chinese People's Armed Police Forces, Beijing 100039, China; Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Inhibitory effects of prostaglandin E_1 on activation of hepatic stellate cells in rabbits with schistosomiasis[J];国际肝胆胰疾病杂志(英文版);2007-02
7 YANG SHu-De;MA Jian-Min;SUN Juan-Hua;CHEN Duan-Xia;and SONG ZHen-Yu Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing;CLINICAL PHARMACOKINETICS OF A NEW EFFECTIVE ANTIMALARIAL ARTESUNATE, A QINGHAOSU DERIVATIVE[J];The Chinese Journal of Clinical Pharmacology;1985-02
8 ZHAO Kai-Cun, CHEN Zhi-Xi~*, LIN Bing-Liu~*, GUO Xing-Bo~*, Li Guo-Qiao~*, SONG Zhen-Yu(Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing) (Guangzhou College of Traditional Chinese Medicine) ~*;STUDIES ON THE PHASE I CLINICAL PHARMACOKINETICS OF ARTESUNATE AND ARTEMETHER~+[J];The Chinese Journal of Clinical Pharmacology;1988-02
9 CHEN Ming-gang National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention,Shanghai 200025, China;Progress of praziquantel in the treatment of schistosomiasis in foreign countries:a review[J];International Journal of Medical Parasitic Diseases;2006-01
10 HUANG Yi-xin~1 WU Yu-long~2 GUAN Xiao-hong~3 ZHAN Zhen~3 JIANG Zuo jun~4 XIAO Shu-hua~5 1.Jiangsu Institute of Parasitic Diseases,Wuxi 214064,China 2.Binzhou Medical College,Binzhou 256603,China 3.Nanjing Medical University,Nanjing 210029,China 4.Ministry of Health,People's Republic of China,Beijing 100044,China 5.National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention,Shanghai 200025,China;Immune-dependence and immune-synergy of praziquantel:a review[J];International Journal of Medical Parasitic Diseases;2006-05
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 PU Xiu-ying,FU Xuan-ying,WANG Qi,JING Tao(The Department of Aetiology,Lanzhou University,Lanzhou,Gansu 730000,China);Change of Immunity and Part Enzymes in Liver Tissue of Mouse Infected with Echinococcosis Treated with Artesunate[J];Endemic Diseases Bulletin;2006-01
2 HOU Xun-ya,LI Yue-sheng. Hunan Institute of Parasitic Diseases, Yueyang 414000, China;Progress in research and application of artemether for schistosomiasis control[J];International Journal of Medical Parasitic Diseases;2006-02
3 ZHOU Jun, WU Guang hua. Military Medical Institute of Nanjing Command, Nanjing 210002, China;Development of the drug to prevent schistosomiasis japonica[J];Chinese Journal of Disease Control and Prevention;2002-01
4 Zhu Weixing, Gu Jun. Department of Dermatology, Changhai Hospital, Second Military Medical University, Shanghai 200433;Effect of artesunate on serum levels of interlukin-6 and transforming growth factor-β in SLE-like mice[J];China Journal of Leprosy and Skin Diseases;2004-04
5 Hou Xunya, Luo Xinsong, Fu Xiao, Zhou Jie, Shi Mongzhi, Liu Zongchuan, Wang Yuanyuan, Li Ying, Li Yuesheng. Hunan Provincial Institute of Schistosomiasis Control,Yueyang 414000, China.;Therapeutic efficacy of praziquantel at two different dosage to rabbit infected with Schistosoma Japonicum[J];Journal of Tropical Diseases and Parasitology;2006-02
6 SONG Yu,BAO Zi-ping,GAO Zu-lu,NIN An,HU Qi-long,CHEN Ming-gang,CHEN Fan-jing,GE Jun,XIAO Shu-hua,ZHOU Xiao-nong,XU Jing(Jiangxi Provincial Iinstitute of Parasitic Diseases,Nanchang 330046,China);Effect of Oral Artemether in Controlling Schistosomiasis in A Heavy Endemic Area of Nanji Town,Xinjian County,Jiangxi Province[J];Journal of Tropical Medicine;2006-11
7 Wang Jiancheng,An Yijun and Guo Zengzhu. Beijing Tropical Medicine Research Institute,Beijing,100050,China;An experimental study on the prophylaxis and therapy of Pneumocystis carinii pneumonia with dihydroarteminsinin[J];Journal of Clinical and Experimental Medicine;2002-01
8 Ge Jihua 1 , Wang Tianping 1 , Lu Dabing 1 ,Zhang Shiqing 1 , Zhang Gonghua 1 , Xiao Xiang 1 , Yao Cixiang 2 , Pan XinPing 3 1 Anhui Provincial Institute of Parasitic Diseases, Wuhu 241000; 2 Veterinary Station of Tongli;STUDIES ON PREVENTIVE EFFECT OF ARTEMETHER AGAINST SCHISTOSOMIASIS IN CATTLE[J];Chinese Journal of Schistosomiasis Contral;2001-04
9 ;Study on prevention and cure of artemeth er against schistosomiasis[J];Chinese Journal of Schistosomiasis Control;2005-04
10 Chen Honggen~1, Lin Dandan~1, Li Yuesheng~2, Liu Yuemin~1, Donald P. McManus~3, Huang Xinghua~4, Feng Zheng~5 (1 Jiangxi Provincial Institute of Parasitic Diseases, Nanchang 330046, China; 2 Hunan Provincial Institute of Parasitic Diseases, China; 3 The QIMR, University of Queensland, Queensland 4029, Australia; 4 Yugan Anti-schistosomiasis Station, China; 5 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, China);Studies on effect of artemether to control infection and prevent acute infection of Schistosoma japonicum in high endemic areas[J];Chinese Journal of Schistosomiasis Control;2006-01
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