Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Pharmaceutica Sinica》 1987-04
Add to Favorite Get Latest Update

EFFECTS OF OXYMATRINE ON THE ANTITUMOR ACTIVITY AND TOXICITY OF CYCLOPHOSPHAMIDE IN MICE

YUAN Cai, LU Shi-Qi and YAO Xian (Department of Pharmacology, Capital Institute of Medicine, Beijing)  
Oxymatrine (OMT) was isolated from Sophora flavescens Alt. Studies showed that the content of hepatic microsomal cytochrome P-450 (P-450) was significantly increased by OMT (100mg/kg). Increased antitumor effect and content of P-450 were found in Ehrlich carcinoma-bearing mice with OMT (100mg/kg) plus cyclophosphamide (CPA) (60 mg/kg). The synergism of antitumor effect was due to increased level of alkylating metabolites of CPA by OMT. Furthermore, antitumor effect of OMT (100mg/kg) plus CPA (30mg/kg) was similar to that of CPA (60mg/kg) but inhibitory effect of CPA on WBC was reduced.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Xiao-chao1),SHEN Ying1),CHEN Peng1),SHEN Zhi-qiang1),GAO Ji-zhe2),YAO Rongcheng3)(1) School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical University,Kunming Yunnan 650500;2) Haerbin Deqiang College of Commerce,Haerbin Hei Long-jiang 150025;3) Pharmacy Department of the First People’s Hospital of Qujing,Qujing Yunnan 655000,China);Anti-inflammatory and Analgesic Effects of Sophora Flavescens Capsule[J];昆明医科大学学报;2013-02
2 GUO Xiao-dong,JIANG Ting-hui,,ZHANG Wei-wei,ZHANG Xue-min,HAN Ke-qi(Department of Tumor,Shanghai Yueyang Hosptail of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China);Clinical observation on kurorinone in preventing hepatic injury caused by chemotherapy[J];中国临床药理学杂志;2010-05
3 YANG Dao-ke, WANG Ying-jun, ZHU Hong-hai(The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052,China);Study on the apoptosis of colon cancer cell line SW1116 induced by oxymatrine[J];中国医药导报;2008-27
4 MIN Dongyu1,ZHANG Jianwu2,ZHANG Haining3,KONG Lingsi4,MA Tengfei1,GU Shuling1 (1.Department of Pharmacology,Xuzhou Medical College,Xuzhou,Jiangsu 221002,China;2.Department of Pharmacology,Chuanbei Medical College,Nanchong,Sichuan 637100;3,4.Undergraduates,Xuzhou Medical College);Protective effect of oxymatrine against cerebral ischemia injury in rats and mice[J];徐州医学院学报;2008-05
5 Jiang Mei,Yin Shusheng,Jian Qiang,et al;Effect of Oxymatrine in treatment of chronic hepatitis B[J];中国疗养医学;2007-10
6 ZOU Yu1,LI Chuan-gui2,WU Shi-tao1 Dengcunliang,Jiangyufeng,the Infectious disease Department,1(1.The Affiliated Hospital of Luzhou Medical College,Sichuan 646000,China;2.The People's Hospital of Weiyuan,Sichuan 642450,China);Efficacy of hepatitis B virus infection treated with tianqingfuxin in children[J];现代医药卫生;2006-15
7 LIU Jian, ZHANG Ai-guo, JIAO Lu-qing(Jinan Fourth People′s Hospital, Jinan, Shandong 250031, P.R.China);Observation of Composite Radix Sophora Flavescentis Injection and chemotherapy to treat lung cancer[J];中国现代医学杂志;2006-01
8 YAO Zhong-qing, ZHU Hong, WANG Guang-feng ( Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, 210029, China; Nanjing Xiyuan Biology Technology Company Limited, Nanjing, Jiangsu, 210037, China; Shanghai Medical Industry Research Institute, Shanghai, 200437, China);Anti - tumor Effect of Total Alkaloids of Radix Sophorue Tonldnensis[J];南京中医药大学学报;2005-04
9 ZOU Yu, DENG Cun liang (Department of Infectious Diseases, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province,China);Yi Gan San Combined with Boertali for Treating Hepatitis B Virus Infection in Children[J];寄生虫病与感染性疾病;2004-01
10 ZOU Yu, DENG Cun liang (Department of Infectious Diseases,Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China);Therapeutic Efficiency of Boertaili (Oxymatrine) for Treating Hepatitis B in Children[J];寄生虫病与感染性疾病;2003-04
China Proceedings of conference Full-text Database 1 Hits
1 Fang Yuan1a,Jie Chen 2a,Wen-jin Wu 3,Su-zhen Chen 1,Xue-ding Wang 1 and Min Huang 1 1 Institute of Clinical Pharmacology,School of Pharmaceutical Sciences,Sun Yat-sen University,74 Zhongshan Road II,Guangzhou 510080,P.R.China,and 2 Department of Pharmacy,the First Affiliated Hospital,Sun Yat-sen University,58 Zhongshan Road II,Guangzhou 510080,China,and 3 Institution of Chinese Medical Science,University of Macau,Av.Padre Tomás Pereira S.J.,Taipa,Macao,P.R.China.;Effects of matrine and oxymatrine on catalytic activity of cytochrome P450s in rats[A];[C];2011
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Yang Jianchun~1 Wang Chunyan~1 Zhang Qi~1 Han Shuying~2 (1.Women and Children's Hospital of Tangshan,Hebei Tangshan 063000,China;2.Department of Pharmacology,North China Coal Medical University);Effects of Compound Minning Liniment (CML) on Mesenteric Microcirculation in Rats and Capillary Permeability in Mice[J];中国药师;2008-11
2 YE Ai-qin,LV Jian-feng,LIU HuaDepartment of Oncology,Taixing People’s Hospital of Jiangsu,Taixing 225400,China;Clinical Observation of Liver Function Damage Induced by L-OHP[J];肿瘤防治研究;2007-10
3 FU Ping, FENG Mei, ZHANG Zhu, et al Department of Nephrology, Huaxi Hospital, Sichuan University, Chengdu (450000);Experimental Study on Effect of Matrine in Alleviating Renal Tubulointerstitial Fibrosis in Unilateral Ureteral Obstruction Model[J];中国中西医结合杂志;2006-02
4 ZHANG Ling-na,LI Bing,BAI Jie.(Ningxia Medical College,Yinchuan,750001,China);Experimental Research into the Influence of Oxymatrine on Rats with Epilepsy Induced by Penicillin[J];山西中医;2005-04
5 MA Ling di *, ZHANG Yan, WEN Shi hong, HE Yu juan, LIU Xiao shan, KANG Ge fei, JIANG Ji kai. Department of Clinical Experimental Medicine, Chongqing University of Medical Sciences, Chongqing 400016, China;Inhibition of tumor growth in tumor bearing mice treated with matrine[J];中华肿瘤杂志;2005-06
6 TUO Xin-lan1, BAI Ming2(1. School of Medicine and Life Science, Jianghan University, Wuhan, Hubei 430022, P.R.China; 2. Xiehe Hospital, Tongjin Medical College, Huazhong University of Science and Technology, Wuhan Hubei 430022, P.R.China);Expression and significance of human mismatch repair gene (sMSH2) and proliferating cell nuclear antigen (PCNA) in lung cancer[J];中国现代医学杂志;2005-05
7 YANG Gui-zheng 1, GUO Jing-sheng 2 (1.Center of Medicinal Education of Tianjing,Tianjing 300400,China; 2.The Sixth TCM Pharmaceutical Factory,Tianjing 300401,China);EXPERIMENTAL STUDY ON ANTIARRHYTHMIC ROLE OF SOPHOCARPIDINE DROP[J];河北医科大学学报;2004-03
8 ZOU Yu, DENG Cun liang (Department of Infectious Diseases,Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China);Therapeutic Efficiency of Boertaili (Oxymatrine) for Treating Hepatitis B in Children[J];寄生虫病与感染性疾病;2003-04
9 Chen Wei ,Zhou Zheng ,Yin Yibing Laboratory Department,Research Institute of Surgery ,Duping Hospital,Third Military Medical University ,Chong qing 400042;RESEARCH PROGRESS IN RELATIONSHIP BETWEEN GENE VARIATION OF HEPATITIS B VIRUS AND DRUG THERAPY[J];中国现代医学杂志;2003-18
10 PANG Xiao-Jun, FU Chun-Hui, YANG Ming, LIN Qi-Yun 1 (Qinzhou Second Public Hospital, Qinzhou, Guangxi 535000, 1Pharmacology Teaching and Research Office of Guangxi College of Traditional Chinese Medicine, Nanning 530001);Anti-inflammation of phlegm-dispelling and cough-relieving mixture and external body antibacterial experiment[J];中国药理学通报;2003-05
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Wu Rui;Yu Xinchao;Anhui University of Science and Technology;;Curative effect of sophora flavescens extraction in treatment of enteropathogenic E.coli of infected mice[J];现代医药卫生;2015-05
2 DU Yan-ying;LIU Chang-jiang;LIU Yang-yang;College Food Shenyang Agricultural University;;Optimization of total alkaloids extraction from Actinidia arguta stems using response surface methodology[J];食品工业科技;2015-13
3 Zhang Xinlin;Zhu Lijuan;Huang Ting;Shanghai Chinese Medicine Hospital;;Clinical Studies of Clearing Heat,Circulating Blood and Eliminating Swelling Prescription Treatment of Postoperative Complications of Mixed Hemorrhoids[J];中医学报;2014-03
4 WANG Mei-ying;WEI Kun-hua;YANG Zhen-de;MIAO Jian-hua;WEI Rong-chang;YANG Ming-yan;College of Forestry,Guangxi University;Guangxi Botanical Garden of Medicinal Plants;;Effects of Different Sources of LED on Biomass and Active Components Contents of Sophora tonkinensis Seedlings[J];湖北农业科学;2013-23
5 SU Rui;LI Ling;XU Hong-bin;HUANG Fang;Anhui University of TCM;The Affiliated Tenth People's Hospital,Tong ji University;;A Systematic Review of Therapeutic Efficacy and Safety of Adjuvant Therapy of Compound Sophora flavescens Injection in the Treatment of Tumor[J];中国药房;2013-44
6 ZHANG Yan;SHI Yu-sheng;CHEN Miao;TANG Zhi-guo;CHEN Xiao-zhong;Jiamusi College,Heilongjiang University of Chinese Medicine;Traditional Chinese Medicine Department,Medical College of Soochow University;Suihua Food and Drug Inspection of Heilongjiang Province;;Research Progress of Biological Activity of Uietnamese Sophora Root[J];中医药学报;2013-05
7 LI Fei1,LI Cheng-ping1*,FU Hui1,SU Xiao-li2*,WANG Zhao-ji3,HOU Xiao-rong1,LIN Rui-chao2,GUAN Xi-yao3,LIU Qiu-ming3(1.Zhejiang University of Technology,Hangzhou 310014,China;2.National Institutes for Food and Drug Control,Beijing 100050,China;3.Government Laboratory HKSAR,China);Research progress of Radix Sophorae Tonkinensis and supplementary reports of assay method for toxic chemical composition[J];药物分析杂志;2013-08
8 WANG Qinglan Department of Oncology,Laiwu People's Hospital,Shandong Province,Laiwu 271100,China;Effect analysis of anti liver damage of Oxymatrine Glucose Injection in hepatic hemangioma during chemotherapy[J];中国医药导报;2013-11
9 FAN Yue WANG Shiming SHI Qingqing Department of General Surgery, the First Hospital of Shanxi Medical University in Shanxi Province, Taiyuan 030001, China;The influence of hepatic carcinoma HepG2 cell proliferation and its cellular autophagy by matrine[J];中国当代医药;2013-07
10 QIAO Hongwei,CHEN Lixia Department of Oncology,The First Affiliated Hospital of Baotou Medical College,Inner Mongolia Baotou 014010,China.;Clinical observation of Fentany transdermal patches combined with compound matrine injection in the treatment of cancer pain[J];现代肿瘤医学;2012-11
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved