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《Acta Pharmaceutica Sinica》 1987-12
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ANTITUMOR ACTIVITY OF BLEOMYCIN A_6 AGAINST HUMAN LIVER CANCER IN CELL CULTURE AND IN NUDE MICE

JIANG Min and ZHEN Yong-Su (Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing)  
The cytotoxicity of bleomycin As on human cell lines derived from liver cancer (BEL-7402), nasopharyngeal cancer (CNE-2) and stomach cancer (MGc-803) was evaluated with clonogenic assay. Bleomycin A_6 was found to be highly active against these three cell lines, especially liver cancer cells. The IC_(50) value of bleomycin A_6 for liver cancer BEL-7402 cells was 6×10~(-11) mol/L. As shown by flow cytophotometry, bleomycin A_6 blocked the growth of liver cancer cells at G_2 phase. At a tolerable dosage level, bleomycin A_6 exhibited remarkable growth inhibiton on human liver cancer xenograft in nude mice with an inhibition rate of 75%. These observations suggest that bleomycin A_6 may be useful in human liver cancer chemotherapy.
【Fund】: 国家自然科学基金
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