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《Acta Pharmaceutica Sinica》 1988-09
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ZHENGGUANGMYCIN A_6 AND ITS STATUS IN THE COMPLEX OF ZHENGGUANGMYCINS

HZ Xu, LH Dai~*, HY Zhang~(**), GY Zhao, XR Zhang and GS Zhang (Institute of Medicinal Biolechnology, Chinese Academy of Medical Sciences, Beijing) (?)ei Pharmaceutical Factory, Tianjin; ** North China Pharmaceutical Factory, Shijiazhuang  
Based on physico-chemical properties and analysis of spectra, zhengguangmycin A_6 was identified as bleomycin A_6. As reported in literature, the addition of a certain amine to the fermentation media increased the ratio of production of the bleomycin which contains the added amine as the terminal moiety. Spermidine (0.36 mg/ml) Was very efficiently incorporated into bleomyein A_5 and completely suppressed the production of other bleomycins. However, it is an exception for bleomycin A_6, which is present in natural bleomycins in only trace amounts, even after the addition of its terminal amine (spermine 0.30 mg/ml) to the fermentation media. But the amount of zhengguangmycin A_6 is different. Under normal conditions the amount of zhengguangmycin A_6 in natural zhengguangmycins is usually over 10%, in some batches, reaching 15% and was the second important component in an amount next to zhengguangmycin A_5 (pingyangmycin). This suggests that the producing strain of zhengguangmycins, Streptomyces verticillus var. pingyangensis nov. is different from that of bleomycin, S. verticillus.
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