SYNTHESES OF 1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-7-[(4-P-NITROBENZOL)-1-PIPERAZINYL] QUINOLINE-3-CARBOXYLIC ACID AND ITS ANALOGUES
HC Chen YC Guo and DR Lu (Department of Chemistry, Zhengzhou University, Zhengzhou 450052)
Syntheses of thirteen new compounds of 1-ethyl-6-flouro-1, 4 - dihydro - 4 - oxo - 7 - [(4- p- nitrobenzoyl)1 - piperazinyl] quinoline - 3 - carboxylic acid and its analogues are reported. The structures were determined by IR, ~1HNMR and elemental analysis, Four compounds have been subjected to antibacterial activity tests in vitro. Compound I_1 was shown to have significant activity.