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《Acta Pharmaceutica Sinica》 1991-10
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STUDIES ON PYRIDONECARBOXYLIC ACIDS AS ANTIBACTERIAL AGENTS Ⅹ. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 1, 7 - DISUBSTITUTED-6-FLUORO-1, 4- DIHYDRO-4-OXO- QUINOLINE-3-CARBOXYLIC ACIDS

JX Chen and HY Guo (Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing 100050)  
A series of pyridonecarboxylic acids were prepared. These compounds have different groups including substituted benzenes, fiwans and isoxazles at the 1-position, or different substituted amino groups at the 7-position. The in vitro antibacterial potencies of these compounds against E. coli. and S. aureus were tested, and structure- activity relationships were discussed.
【Fund】: 中国医学科学院科研基金
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