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《Acta Pharmaceutica Sinica》 1993-06
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SYNTHESIS AND ANTIBACTERIAL ACTION OF 1-ETHYL-6-FLUORO-1, 4-DIHYDRO- 4-OXO-7-(4-AROYLTHIOCARBAMOYL-1 -PIPERAZINYL)- 3-QUINOLINE CARBOXYLIC ACIDS

XS Jia, YL Wang~*, FS He~(**), YF Shan~(**), YF Li~(**) and Y Wang~(***)(Department of Chemistry, Henan Normal University, Xinxiang 453002; ~(**)Department of Biology, Henan Normal University, Xinxiang 453002)  
Thirteen new 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-aroyl-thiocarbamoyl- 1 piperazinyl)-3-quinoline carboxylic acids were prepared, Their structures were characterized by elemental analysis, IR, HNMR and MS spectra.Preliminary pharmacological tests indicated that some of compounds Ia~m possess strong inhibiting activity against Escherichia coli, Bacillus subtilis and Proteus at concentration of 100 μg/ml.
【Fund】: 河南省科委自然科学基金
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