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《Acta Pharmaceutica Sinica》 1993-11
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SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF 1-AMINO-6-FLUORO-1,4-DIHYDRO-4-OXO-7-(SUBSTITUTED) PIPERAZINYL-3-QUINOLINECARBOXYLIC ACIDS AND THEIR DERIVATIVES

T Xin, J Ding and XP Zhang (Shanghai Institute of Pharmaceutical Industry, Shanghai 200437)  
The title compounds 6~24 were obtained by the reaction of 5 with corresponding benzaldehydes. 5 wes prepared with ethyl 7-chloro-6-fluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylate by hydrolysis, amination and condensation with piperazine. Anti—bacterical activities of 5~24 were tested in vitro.
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