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《ACTA PHARMACEUTICA SINICA》 2000-01
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FORMATION AND PHYSICAL CHEMISTRY CHARACTERIZATION OF THE PHOSPHATIDYCHOLINE MICROEMULSIONS

Lu Ying, Jiang Xuetao and Zeng Renjie 1 (Department of Pharmacy, The Second Military Medical University, Shanghai 200433; 1Department of Pharmacy, Chengdu Military General Hospital, Chengdu 610083)  
AIM: To study the formation of microemulsion phases at 25℃ for systems containing soybean phosphatidylcholine and the effect of formulation variables on the physical chemistry characterization of microemulsion. METHODS: High purity lecithin (PC96%) was used as surfactant, several short chain alcohols (i.e. ethanol, n propanol, n butanol, n pentanol) were investigated as cosurfactant and isopropyl myristate as oil. Viscosity, conductance, refraction and mean droplet diameters of the microemulsions were measured. RESULTS: In each system studied, w/o microemulsion could be observed along the surfactant /oil axis. All microemulsions were stable at room temperature for several months. The physicochemical properties of lecithin microemulsions were influenced by the formulation variables: conductance and mean droplet diameter increased as the proportion of water increased; the proportion of water and the ratio of lecithin/ethanol ( K m) showed predominant influence on the viscosity of the microemulsion. CONCLUSION: The extent of the regions of the microemulsion was dependent upon the nature of the cosurfactant and the oil and also the lecithin/cosurfactant mixing ratio ( K m). The IPM/PC/ethanol/water system was chosen to produce O/W microemulsions used for drug delivery. The formulation that has relatively large K m and medium proportion of water was better to be used in drug delivery system.
【CateGory Index】: R943
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