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《ACTA PHARMACEUTICA SINICA》 2000-04
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EFFECT OF ICARIIN AND ITS METABOLITES ON THE PRODUCTION OF CYTOKINES BY THP-1 CELLS

Liu Tiehan, Wang Benxiang, Wang Yi, Guo Yingjie, Wu Lijun 1, Mutsuhiko Minami 2, Toshi Nagata 3 and Takashi Ikejima 3 (New Drug Research Center, Changchun College of Traditional Chinese Medicine, Changchun 130021; 1Research Department o  
AIM: To study the effects of icariin and its metabolites (baohuoside I, icaritin) on the production of proinflammatory cytokines by THP 1 cells. METHODS: Radioimmunoassay (RIA) was used to quantitate human IL 1α, IL 6, IL 8 and TNFα. RESULTS: Icariin and its metabolites were shown to stimulate production of IL 6 and inhibit production of IL 8 and TNFα in the presence of LPS and PMA. In the absence of LPS and PMA these metabolites stimulated IL 8 production, but suppressed IL 6 production. Whether LPS and PMA were used or not, icariin and its metabolites have significant inhibitory effect on the production of IL 1α. CONCLUSION: These findings suggest that icariin and its metabolites, baohuoside I and icaritin, have modulatory effect on the production of cytokines.
【Key Words】： icariin baohuosode I icaritin cytokines THP-1 cell line radioimmunoassay (RIA)
【Fund】： 国家中医药管理局资助课题 ;; 日中医学协会及万有制药株式会社资助
【CateGory Index】： R285
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