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《Acta Pharmaceutica Sinica》 2001-01
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APPLICATION OF TRIANGULAR PHASE DIAGRAMS TO INVESTIGATE THE FORMULATION CONDITIONS OF PHARMACEUTICAL MICROEMULSIONS

WT4”,5BZ]LU Bin, ZHANG Zheng quan (School of Pharmacy, West China University of Medical Sciences, Chengdu 610041, China) [WT4”,5HZ]  
AIM To establish innovational triangular phase diagrams for preparation of pharmaceutical microemulsion (ME) with low toxicity as a result of reducing the amount of the emulsifiers. METHODS Lecithin and polyoxyethylene octyl phenyl ether (OP) were used as emulsifiers (E), absolute alcohol and n octyl alcohol as assistant emulsifiers (A), ethyl oleate and olive oil as the oil phase (O). For the innovational triangular phase diagrams, lecithin ethyl oleate water and absolute alcohol (optimized ratio W/A=0 6)system, and OP(olive oil and n octyl alcohol (O/A=0 34) water system were used for preparation of the ME. While for the traditional triangular phase diagrams, OP and n octyl alcohol (E/A= K m=1 5) olive oil water system, lecithin and absolute alcohol (E/A= K m=1 12) ethyl oleate water system were used. Then, the corresponding amounts of the emulsifiers used in both methods were compared. RESULTS In the ME of lecithin systems by the innovational and the traditional methods, the amounts of emulsifier are 6%-28% and 28%-29 6%, respectively. In the ME of OP systems by the innovational and the traditional methods, the amounts of emulsifier are 23%-40% and 27 6%-49 8%, respectively. CONCLUSION The method of innovational triangular phase diagram for preparation of ME is superior to the traditional method in finding out the lower amounts of emulsifiers for ME, and is a feasible method with guiding significance for preparing ME.
【CateGory Index】: R94
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【References】
Chinese Journal Full-text Database 10 Hits
1 LI Nan;LI Xi-jing;WANG Qian;Tianjin Institute of Pharmaceutical Science;;Preparation of Curcumin Solid Lipid Nanoparticles by Microemulsion Method[J];中国药房;2015-19
2 Zhuang Yuting;Ji Hongyu;Tang Jingling;Mao Yuting;Liu Hongmei;Zheng Dongyou;Wu Linhua;Department of Pharmacy,the Second Affiliated Hospital of Harbin Medical University;College of Pharmacy,Harbin Medical University;Key Laboratory of Drug Research,College of Heilongjiang Province;;Application of Microemulsions on Transdermal Delivery Systems[J];中国药师;2015-01
3 YAO Yi-jing;GUO Bing-yu;HAN Jing;LI Ming;CEN Qin;Shenyang Pharmaceutical University;Food and Drug Administration of Lijin County;Shenyang Product Quality Supervision and Inspection Institute;;Optimization of self-microemulsifying drug delivery system for paclitaxel by central composite design-response surface method[J];中南药学;2014-11
4 LI Lei;WANG Chang-yuan;CAI Yun;GAO Peng-cheng;TIAN Yan;LIU Ke-xin;School of Pharmacy,Dalian Medical University;;Preparation and Pharmacokinetics of JBP 485-loaded W /O Microemulsion for Oral Delivery[J];医药导报;2014-02
5 ZHAO Hui-ru;ZHANG Peng;YANG Rui;GUO Ting;Department of Pharmacy,Xi'an Medical College;Department of Pharmacy,The People's Hospital of Shannxi Province;;Optimization of preparation technology of quercetin microemulsion[J];中国医院药学杂志;2013-20
6 Kuang Fu 1,Xiao Tingchao 2,Zhu Zhaojing 3,Qian Yan 1( 1.Department of Pharmacy,Second Affiliated Hospital,Chongqing Medical University,Chongqing,China 400010;2.Library,Chongqing Medical University,Chongqing,China 400016;3.Chongqing Medical and Pharamaccutical College,Chongqing,China 400030);Study on Erythromycin Self-Microemulsifying Preparation Prescription[J];中国药业;2013-14
7 ZHENG Xing-xing,OUYANG Wu-qing,GUO Jian-jun,ZHOU Ying,SONG Guan-nan(College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi 712100,China);Preparation of cefixime nanoemulsion and determination of its bacteriostatic activity and acute toxicity in vitro[J];西北农林科技大学学报(自然科学版);2013-07
8 ZHENG Xing-xing,OUYANG Wu-qing,ZHOU Ying,GUO Jian-jun,SONG Guan-nan(College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi 712100,China);Preparation of fluconazole nanoemulsion and its antifungal activity in vitro[J];西北农林科技大学学报(自然科学版);2013-02
9 CUI Qing-hua,WEI Dong-qing,LI Wan-zhong,TIAN Jing-zhen(Shandong University of Traditional Chinese Medicine,Jinan 250355,China);Study on prescription screening and preparation technology of oryzanol solid self-microemulsion[J];齐鲁药事;2012-10
10 RUI Xian,OUYANG Wu-qing,WU Jing-chao,SONG Bing,LIU Mei-xue,DONG Rui(College of Veterinary Medicin,Northwest A&F University,Yangling 712100,China);Preparation and quality evaluation of natamycin nanoemulsion[J];中国新药杂志;2012-17
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 AN Chang-yong1,XIE Gang1,TANG Wei-xue2,YANG Xiao-ding1,ZHANG Cai-quan1 1Department of Gastrointestinal Surgery,First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China;2Chongqing Key Laboratory of Neurology,Chongqing Medical University,Chongqing 400016,China;Effect of Quercetin on proliferation and invasion of colon carcinoma LOVO cells and the expression level of carcinoembryonic antigen[J];中国临床药理学与治疗学;2013-01
2 WANG Gang1,2,DU Shi-Ming2,CHANG Ming-Quan2,ZENG Nan1,YE Fang2,CHEN Yong-shun2(1.Chengdu University of TCM,Sichuan Chendu 610075,Chian;2.Department of Pharmacy,Taihe Affiliated Hospital of Hubei Medical College Hubei Shiyan 442000,China);Preparation and Pharmacokinetic Study Long Circulating Nano-Liposomes of Quercetin in Rats[J];医药导报;2012-10
3 WANG Gang1,2,DU Shi-ming1,YANG Guang-yi1,CHANG Ming-quan1,ZENG Nan2,YE Fang1(1.Department of Pharmacy,Taihe Affiliated Hospital of Hubei Medical College,Hubei Shiyan 442000,China;2.Chengdu University of TCM,Sichuan Chengdu 610075,China);Effects of the plasma metabolites of quercetin on rat C6 glioma cells[J];中国医院药学杂志;2012-16
4 YANG Kun1,YANG Ya1,LIU Han1,LUO Zhang1,ZHU Xin1, CHEN Xiao-jun2,LI Xiao-wen2,SUN Zhi-liang2(1.Orient Science and Technology College,Hunan Agricultural University,Changsha 410128,China; 2.College of Veterinary Medicine,Hunan Agricultural University,Changsha 410128,China);Study on Acute Toxicity of Florfenicol Suspended Microemulsion to Mice[J];中国兽药杂志;2012-05
5 ZHANG Cai-ke,BAI Jing,YU Hui,SHEN Zheng-hua,LE Guo-wei* State Key Laboratory of Food Science and Technology,Jiangnan University; School of Food Science and Technology,Wuxi 214122,China;Effect of Quercetin on Serum Lipid Metabolism of Mice and Its Antioxidant Activity in Vitro[J];天然产物研究与开发;2012-05
6 DONG Wenxue,HE Jun~*,YANG Yani (National Pharmaceutical Engineering and Research Center,China State Institute of Pharmaceutical Industry,Shanghai 20043 7);Progress in Self-microemulsifying Drug Delivery System[J];中国医药工业杂志;2011-12
7 SUN Dong-ni,WU Ye,NIU Lei,JIN Yun-huan,CHEN Da-wei(School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China);Preparation and physicochemical characteristics of curcumin-loaded long-circulating solid lipid nanoparticles[J];中国药剂学杂志(网络版);2011-06
8 CUI Li-li,DENG Ying-jie,ZHANG Yong,MO Wen-wen (School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China);Formulation and characterization of water-in-oil microemulsions for oral delivery of thymopentin[J];沈阳药科大学学报;2010-08
9 SONG Xiao-jing1,DONG Yan2,ZHANG Hong1,ZHENG Tong-jiao1(1.Dapertment of Oral,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China;2.Oral Medical College,Dalian Medical University,Dalian 116044,China);Observing the susceptibility of candida albicans to fluconazole terbinafine and itraconazole and nystatine by m27-a microdilution method[J];大连医科大学学报;2010-04
10 ZHANG Xu,OUYANG Wuqing*,CHEN Jianmin and HU Shuai(College of Veterinary Medicine,Northwest A&F University,Yangling Shaanxi 712100,China);Preparation and Quality Evaluation of Compound Propolis Nanoemulsion[J];西北农业学报;2010-05
【Secondary References】
Chinese Journal Full-text Database 6 Hits
1 XU Man;YU Qing;ZHAO Qianru;CHEN Wei;LIN Yuanjie;JIN Yong;School of Pharmacy,Anhui Medical University;;Formulation Screening and Determination of Troxerutin Microemulsion[J];医药导报;2015-12
2 GE Min;PENG Jiabei;LE Jiawei;WANG Dingsheng;XIE Minghua;Department of Pharmacy,The First People's Hospital of Yuhang District,Hangzhou;;Preparation and transdermal diffusion characteristics in vitro of lidocaine microemulsion-based gel[J];中国临床药学杂志;2015-06
3 XUE Ji-yang;HAN Li-mei;Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine;School of Pharmacy, Fudan University;;Preparation optimization of paclitaxel-loaded Pluronic P123 polymeric micelles by central composite design-response surface method[J];中南药学;2015-11
4 SU Ben-wei;ZHANG Xie-jun;ZHU Kai-xin;ZHAO Ming-hui;LI Yong-hua;Qinzhou Institute of Traditional Chinese Medicine;Qinzhou Hospital of Traditional Chinese Medicine;Guangxi Traditional Chinese Medicine University,School of Pharmacy;;Optimized extraction conditions for quercetin of Taxilli Herba[J];中国医院药学杂志;2014-19
5 Zhang Huili;Zhengzhou Huaxin College;;Prescription and Technology of Ambroxol Injectable Emulsion[J];中国药业;2014-13
6 ZHAO Hui-ru;ZHAO Yang;Department of Pharmacy,Xi'an Medical College;;Study on effect of O /W microemulsion in enhancing solubility of luteolin[J];应用化工;2014-06
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