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《Acta Pharmaceutica Sinica》 2004-08
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Determination of five components in compound hypotensive tablet by HPLC

CHE Bao-quan * (Beijing Institute for Drug Control, Beijing 100035, China)  
Aim To establish a method for the determination of the five components (reserpine, chlordiazepoxide, hydrochlorothiazide, dihydralazine sulfate, triamterene) in compound hypotensive tablet. Methods The chromatography was performed using a CN column with acetontrile-0.1 mol L -1 sodium heptasulfonate solution (7∶3) and (5∶5) as the mobile phases. The detection wavelength was 267 nm for reserpine, chlordiazepoxide and hydrochlorothiazide, 310 nm for dihydralazine sulfate, 360 nm for triamterene. Results The linear range of each component was tested, and the recovery and stability of each component was satisfactory, three lots of samples were determined using the method. Conclusion This is an accurate and credible quality control method for compound hypotensive tablet.
【Key Words】: compound hypotensive tablet HPLC reserpine triamterene hydrochlorothiazide chlordiazepoxide dihydralazine sulfate
【CateGory Index】: R927.2
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