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《Acta Pharmaceutica Sinica》 2009-11
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Insulin secretion stimulating effects of mogroside V and fruit extract of Luo Han Kuo (Siraitia grosvenori Swingle) fruit extract

ZHOU Ying1, ZHENG Yan2, EBERSOLE Jeff 2, HUANG Chi-fu2 (1. College of Life Science, Guizhou University, Guiyang 550025, China; 2. Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, Kentucky 40503, USA)  
Luo Han Kuo fruit (Siraitia grosvenori Swingle), a fruit native to China, has been used as a natural sweetening agent for centuries and has been reported to be beneficial for diabetic population. However, limited research has been conducted to elucidate the relationship between the sweetening action and biological parameters that may be related to potential health benefits of LHK fruit (Luo Han Kuo fruit). The present study examined the effect of LHK fruit and its chemical components on insulin secretion using an in vitro cell model system. Mogroside V is the most abundant and the sweetest chemical component among the mogrosides in LHK fruit. The experimental data demonstrated that the crude LHK extract stimulated the secretion of insulin in pancreatic beta cells; furthermore, pure mogroside V isolated from LHK fruit also exhibited a significant activity in stimulating insulin secretion by the beta cells, which could partially be responsible for the insulin secretion activity of LHK fruit and fruit extract. The current study supports that LHK fruit/extract has the potential to be natural sweetener with a low glycemic index, and that mogroside V, possible other related mogrosides, can provide a positive health impact on stimulating insulin secretion.
【Fund】: Project supported by National Institute of Dental & Craniofacial Research (NIH/NIDCR (1R41DE017265-01))
【CateGory Index】: R151
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Chinese Journal Full-text Database 2 Hits
1 NIU Xin-jie1, 2, WANG Zuo-ren1, SEUFERT Jochen21Department of Hepatobiliary Surgery, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China; 2Division of Endocrinology and Diabetology, Department of Internal Medicine, Hospital of Freiburg University, Freiburg in Breisgau 95095, Germany;GC-box is not a key cis-acting element in human insulin gene promoter[J];Journal of Southern Medical University;2007-01
2 HUANG Jin-hua.(Department of Endocrinology,the Second Affiliated Hospital of Tianjin Medical University,Tianjin 300211,China);Advances in Relationship between Pancreatic Duodenal Homeobox-1 and Diabetes Mellitus[J];Medical Recapitulate;2008-06
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