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《Acta Pharmaceutica Sinica》 2011-06
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Advances in the structure-activity relationship study of natural flavonoids and its derivatives

ZHONG Jian-qing1,LI Bo2,JIA Qi1,LI Yi-ming1,ZHU Wei-liang2*,CHEN Kai-xian1,2*(1.College of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China; 2.Drug Design and Discovery Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China)  
Flavonoids are a large class of compounds widely distributed in nature.Many pharmacological activities of flavonoids have been reported such as anti-cancer,antioxidant,anti-inflammatory,hepatoprotective,antithrombotic,vasodilator,antiviral,antibacterial,antiallergic,and so on.In recent years,domestic and foreign research groups choose natural flavonoids and optimize their chemical structures in order to develop a number of new derivatives with stronger pharmacological activities.As part of the mechanisms are not clear,we need to strengthen in-depth research in the SAR(structure-activity relationship) study for targeted and efficient structure optimization.This paper systematically summarize current researches in the SAR studies of flavonoids and their derivatives,which can serve as a reference for synthesizing new flavonoid derivatives.
【Fund】: 国家“重大新药创制”科技重大专项资助项目(2009ZX09311)
【CateGory Index】: R284.1
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