Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《ACTA PHARMACEUTICA SINICA》 1994-10
Add to Favorite Get Latest Update

EFFECT OF GLYCYRRHETINIC ACID DNA DAMAGE AND UNSCHEDULED DNA SYNTHESIS INDUCED BY BENZO(α)PYRENE

XG Chen and R Han(Institute of Materia Medica ,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100050)  
Glycyrrhetinic acid(GA)is an active component of Glycyrrhiza uralensis Fisch.Inthis study,the effects of glycyrrhetinic acid on DNA damage and unscheduled DNA synthesis inducedby benzo(α)pyrene were studied.Mouse ear edema was visible obviously at the 6th h after topicalapplication of single dose croton oil.A opical application of croton oil on the back of ICR mice for 5h,induced elevation of ornithine decarboxylase(ODC)activity in epidermal.The administration ofglycyrrhetinic acid(50~200 mg·kg-1·d-1)to animals for 3 days exhibited 20%~80%inhibition of epidermal ornithine decarboxylase activity in a dose-dependent manner.Benzo(α)pyreneobviously caused DNA damage and unscheduled DNA synthesis mediated by S9 fraction in Chinesehamster lung cell line.Glycyrrhetinic acid was found to protect the rapid DNA damage induced bybenzo(α)pyrene.At concentration of 5μg· ml-1,glycyrrhetinic acid exhibited 70% protection.At20μg·ml-1 ,this action was more potent and approached to 80%.The addition of hydroxyurea 10mmol·L-1 suppressed DNA replicative synthesis to 84.4%and benzo(α)pyrene stimulated theDNA repair synthesis(6-fold).Glycyrrhetinic acid(20μg· ml-1 and 50μg·ml-1 significantlydecreased the stimulation of DNA repair synthesis induced by benzo(α)pyrene.This suggests thatglycyrrhetinic acid has effective anti-initiating and ant-promoting activities and could be used forcancer chemopreventive purpose.
【Key Words】: Glycyrrhetinic acid DNA damage protection Unscheduled DNA synthesis Cancerchemoprevention
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 4 Hits
1 Hu Bin , Yang Shute (Shaoyang Tumor Hospital , Shaoyang, Hunan 422001);Life Existing Peacefully with Cancer[J];World Journal of Integrated Traditional and Western Medicine;2006-03
2 Liu Changxi, Gao Peng, Sun Ming, Yan Weixing,et al. Institute of Food Safety Control and Inspection, Ministry of Health, Beijing 100021, China;Study of fungus polysaccharides compounds (FPC) in inducing the apoptosis of liver cancer cell Bel-7402[J];Journal of Hygiene Research;2001-01
3 SUN Xiao-hong~1,SHAO Shi-he~1,LI Hong-tao~1,ZHOU Li-qin~2 (1.Medical College of Beihua University,Jilin 132013,China; 2.Affiliated Hospital of Beihua University,Jilin 132011,China);Research Advance of Glycyrrhiza uralensis Fisch. on Antineoplastic Function and Its Clinical Application[J];Journal of Beihua University(Natural Science);2004-06
4 MA Jing, PENG Wenlie, LIANG Dong, et al. Department of Biochemistry, College of Life Science, Zhongshan University, Guangzhou (510275);Apoptosis of Human Gastric Cancer Cell Line MGC-803 Induced by Glycyrrhiza Uralensis Extract[J];Chinese Journal of Integrated Traditional and Western Medicine;2000-12
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Li Jun-li Yan Rui-qi Wang Hui-yun Huang Mei-lin Huang Xiao-yan(Liver Cancer Leb., Cancer Center, Sun Yat-sen University of Medical Sciences. Guangzhou 510060);EFFECTS OF GLYCYRRHIZIN, SILYMARIN, CITRUS PEAL AND JUICE ON AFLATOXIN B_1-INDUCED HEPATOCARCINOGENESIS IN RATS[J];Chinese Journal of Cancer;1993-02
2 YAN Rui-qi LI Jun-li HUANG Mei-ling HUANG Xiao-yan WANG Hui-yun FENG Qi-sheng (Cancer Institute, Sun Yat-sen University of Medical Sciences. Guangzhou, 510060);PROTECTIVE EFFECT OF GLYCYRRHIZIN ON DNA REPALR DURING ITS INHIBITION ON DEN-INDUCED HEPATOCARCINOGENESIS[J];Chinese Journal of Cancer;1995-04
3 MA Jing1, FU Nai yang2, LI Yu mei3, PENG Wen lie1, XU An long1*1.Department of Biochemistry and Center for Biopharmaceutical Research, College of Life Science, Zhongshan University, Guangzhou 510275, P.R.China2.Institute for Drug Control of Guangdong;Glycyrrhiza uralensis Fisch Extract Selectively Induces Apoptosis in Several Human Cancer Cell Lines in Vitro[J];Chinese Journal of Cancer;2001-08
4 SI Wei ke*, GAO Li hong, LIU Bing, CHENG An, LI Peng, YAO JieDepartment of Clinical Biochemistry, the Third Military Medical University, Chongqing 400038, P.R.China;Regulation of G_1 Phase Cell Cycle Regulation Factors in Differentiation and Apoptosis of Matrine Induced Hepatoma Cells[J];Chinese Journal of Cancer;2001-08
5 Chen Zhengming Wu Qiao Chen Yuqiang, et alThe State Lab. for Tumor Cell Engineering, Xiamen Univ, Xiamen, Fujian, 361005;The effect of retinoic acid on growth inhibition and p53、c mycexpression in gastric carcinoma cells[J];CHINESE JOURNAL OF CANCER;1998-06
6 ZHANG Dongfang, HUANG Wei, HUANG Jiqun, LIAO Zhaoquan. Cancer Institute, Guangzhou Medical College, Guangzhou, Guangdong 510182, P.R.China;Studies on proliferation inhibition and anti-invasion of retinoic acid and 18β-glycyrrhetinic acid in highly metastasized human lung cancer cell line[J];Chinese Journal of Lung Cancer;2003-03
7 Li Chengxiu, et al(Department of Pharmacology, Guigang Medical College);Effects of Glycyrrhizin in Anticancer Activity and Toxicity Induced by Anticancer Drugs[J];JOURNAL OF GUIYANG MEDICAL COLLEGE;1996-03
8 Liu Yang,Zhao Ping,Zhu Xudong et al:China Medical University,Shen Yang 110001;Epidemiological Study on Early Dermal Impairment Induced by Ultraviolet Radiation in Noth East of China[J];JOURNAL OF ENVIRONMENT AND HEALTH;1997-05
9 YU Hua+1, GE Shu-fen+2,WANG Yan-gao+3. (1.Dept. of Stomatology, The General Hospital of Shenyang Military Command, Shenyang 110016, China; 2. Dept. of Oral Maxillofacial Surgery, The First Affiliated Hospital, China Medical University, Shenyang 110001, China; 3. Dept. of Stomatology, The People Hospital of Dawa District, Panjin 124000, China);Inhibition Effect of Glycyrrhizin on Transplanted Mandibular Gland Fibrosarcoma of Mice[J];West China Journal of Stomatology;2004-06
10 Zhao Gang, Wang Xuemin, Jiang Wei,et al. Department of Emergency Medicine, Shanghai Sixth People’s Hospital, Shanghai 200233 CHINA;The effect of heat stress response on the proteinase release from LPS stimulated neutrophils[J];The Journal of Clinical Anesthesiology;2006-05
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 MA Jing1, FU Nai yang2, LI Yu mei3, PENG Wen lie1, XU An long1*1.Department of Biochemistry and Center for Biopharmaceutical Research, College of Life Science, Zhongshan University, Guangzhou 510275, P.R.China2.Institute for Drug Control of Guangdong;Glycyrrhiza uralensis Fisch Extract Selectively Induces Apoptosis in Several Human Cancer Cell Lines in Vitro[J];Chinese Journal of Cancer;2001-08
2 WANG Jianguo,ZHOU Zhong,LIU Haifeng,WANG Jianxin(School of Chemical and Material Engineering,Southern Yangtze University,Wuxi214036,China);Study of inhibitory capability of active constituents from glycyrrhiza fisch against tyrosinase activity[J];China Surfactant Detergent & Cosmetics;2003-04
3 ZHANG Ming-fa,SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co Ltd.,Shanghai 201423,China);Anticancer activities of crude extracts of licorice and its flavonoids[J];Drugs & Clinic;2010-02
4 WANG Jian-guo1,LIU Xiao-feng1,HUANG Zhi-jun1,WANG Jian-xin2(1 School of Chemistry and Chemical Engineering,Jiujiang University,Jiangxi Jiujiang 332005;2 School of Chemical and Material Engineering,Southern Yangtze University,Jiangsu Wuxi 214036,China);Study on the Extraction of Liquiritigenin and Isoliquiritigenin[J];Guangzhou Chemical Industry;2010-01
5 ZHANG Ze-sheng, SHI Shen; BAI Xin; YANG Hai-yan (Department of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China);Quality Evaluation of Sinkiang Glycyrrhiza and Extraction of Glycyrrhiza Polysaccharide[J];Modern Food Science and Technology;2008-02
6 ZHAO Long-xuan~(1,2),ZHANG Xiao-cui~1,ZHAO Chun-hui~2,SHEN Ping~1,YANG Jun-wei~1, TANG Yao~1 (1.School of Chemistry and Chemical Engineering,Liaoning Normal University,Dalian 116029,China; 2.Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery,Liaoning Normal University,Dalian 116029, China);Synthesis and Characterization of Glycyrrhetinic Acid Derivatives[J];Journal of Dalian University;2011-03
7 WU Xin-jun~(1,2), MAO Pei-hong~(1,3), JIN Xiang~(1,3),ZENG Xian-xian~(1,3) (1. Ion Beam Bio-Engineering Center, Xinjiang University, Urumqi 830008, China; 2. College of Chemistry and Chemical Industry, Xinjiang University, Urumqi 830046, China; 3. Department of Physics, Xinjiang University, Urumqi 830046 , China);Study on Polysaccharide from Edible and Medical Fungus[J];;2004-01
8 YANG Guo-hui1,SHI De-cheng2 (1.Dean's Office,Jilin Academy of Agricultural Science and Technology, Jilin 132101 Jilin,China; 2.Life Science College,Northeast Normal University, Changchun 130024,China);Effects on Osmotic and pH Adjustment Substances of Glycyrrhiza uralensis Fisch to NaCl and Na_2CO_3 Stresses[J];Hubei Agricultural Sciences;2009-04
9 YANG Guo-hui1,SHI De-cheng2(1.Dean's Office,Jilin College of Agricultural Science and Technology,Jilin 132101,Jilin,China;2.Life Science College,Northeast Normal University,Changchun 130024,China);Physiological Responses of Glycyrrhiza uralensis Fisch to NaCl and Na_2CO_3 Stresses[J];Hubei Agricultural Sciences;2009-05
10 YANG Guo-hui1,SHI De-cheng2(1.Dean's Office,Jilin Academy of Agricultural Sciences and Technology,Jilin 132101,Jilin,China;2.College of Life Science,Northeast Normal University,Changchun 130024,China);Effects of NaCl and Na2CO3 Stresses on Lipid Peroxidation in Glycyrrhiza uralensis Fisch[J];Hubei Agricultural Sciences;2009-10
China Proceedings of conference Full-text Database 1 Hits
1 WANG Jian-guo ZHOU Zhong LIU Hai-fen WANG Jian-xin (School of Chemical and Material Engineering, Southern Yangtze University, Wuxi 214036, China);The New Application of Glycyrrhiza to Cosmetics[A];[C];2002
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved