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《ACTA PHARMACEUTICA SINICA》 1999-02
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STUDIES ON SYNTHESIS ANTIBACTERIAL AND ANTITUMOR ACTIVITY OF (S) (-) OFLOXACIN ANALOGUES

Yang Yushe(Yang YS), Ji Ruyun(Ji RY), Chen Kaixian(Chen KX) and Ding Jian(Ding J) (Shanghai Institute of Materia Medica, Shanghai 200031)  
AIM: To design and prepare quinolone compounds with antibacterial and antitumor activities. METHODS AND RESULTS: According to rational drug design principle, a series of novel analogues of (S) (-) ofloxacin has been prepared and the influences on structure activity relationships was also discussed. CONCLUSION: Their in vitro antitumor and antibacterial activities were evaluated. The results showed that compound 16~20 have good antitumor and antibacterial activities.
【Fund】: 国家自然科学基金 上海市科技启明星计划资助项目
【CateGory Index】: R914.5
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