STUDIES ON SYNTHESIS ANTIBACTERIAL AND ANTITUMOR ACTIVITY OF (S) (-) OFLOXACIN ANALOGUES
Yang Yushe(Yang YS), Ji Ruyun(Ji RY), Chen Kaixian(Chen KX) and Ding Jian(Ding J) (Shanghai Institute of Materia Medica, Shanghai 200031)
AIM: To design and prepare quinolone compounds with antibacterial and antitumor activities. METHODS AND RESULTS: According to rational drug design principle, a series of novel analogues of (S) (-) ofloxacin has been prepared and the influences on structure activity relationships was also discussed. CONCLUSION: Their in vitro antitumor and antibacterial activities were evaluated. The results showed that compound 16～20 have good antitumor and antibacterial activities.