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《ACTA PHARMACEUTICA SINICA》 1999-03
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SYNTHESIS AND STRUCTURE ACTIVITIES RELATIONSHIP OF LEVOFLOXACIN ANALOGUES

Yang Yushe(Yang YS), Ji Ruyun(Ji RY), Hu zengjian(Hu ZJ), Chen Kaixian(Chen KX) and Wu Jimin(Wu JM) (Shanghai Institute of Materia Medica, Shanghai 200031)  
AIM: To discover new potent quinolone antibacterial agents. METHODS AND RESULTS: A series of novel analogues of levofloxacin has been prepared. These compounds were evaluated for in vitro activity by determining minimum inhibitory concentrations against a variety of bacteria. The structure activity relationships were also discussed. CONCLUSION: The results showed that the 8 amino group was very favorable for antibacterial activity. Compounds 13 and 14 were superior to the reference compounds levofloxacin and ciprofloxacin and were selected as promising candidates for further studies.
【Fund】: 国家自然科学基金
【CateGory Index】: TQ460.1
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